Host- rather than virus-related factors reduce health-related quality of life in hepatitis C virus infection

Article Article scientifique Article Host- rather than virus-related factors reduce health-related quality of life in hepatitis C virus infection eng 2008 author Helbling Beat author Overbeck Kathrin author Gonvers Jean-Jacques author Malinverni Raffaele author Dufour Jean-François author Borovicka J. author Heimendinger Mireille 100202 author Cerny A. author Negro Francesco 96509 author Bucher Della Sophie author Rickenbach M. author Renner E.L. author Mullhaupt Beat 1597-1603 10.1136/gut.2007.142844 18625696 0017-5749 http://gut.bmj.com/cgi/content/full/57/11/1597 BACKGROUND: Hepatitis C virus (HCV) infection is associated with decreased health-related quality of life (HRQOL). Although HCV has been suggested to directly impair neuropsychiatric functions, other factors may also play a role. PATIENTS AND METHODS: In this cross-sectional study, we assessed the impact of various host-, disease- and virus-related factors on HRQOL in a large, unselected population of anti-HCV-positive subjects. All individuals (n = 1736) enrolled in the Swiss Hepatitis C Cohort Study (SCCS) were asked to complete the Short Form 36 (SF-36) and the Hospital Anxiety Depression Scale (HADS). RESULTS: 833 patients (48%) returned the questionnaires. Survey participants had significantly worse scores in both assessment instruments when compared to a general population. By multivariable analysis, reduced HRQOL (mental and physical summary scores of SF-36) was independently associated with income. In addition, a low physical summary score was associated with age and diabetes, whereas a low mental summary score was associated with intravenous drug use. HADS anxiety and depression scores were independently associated with income and intravenous drug use. In addition, HADS depression score was associated with diabetes. None of the SF-36 or HADS scores correlated with either the presence or the level of serum HCV RNA. In particular, SF-36 and HADS scores were comparable in 555 HCV RNA-positive and 262 HCV RNA-negative individuals. CONCLUSIONS: Anti-HCV-positive subjects have decreased HRQOL compared to controls. The magnitude of this decrease was clinically important for the SF-36 vitality score. Host and environmental, rather than viral factors, seem to impact on HRQOL level. Adult Cross-Sectional Studies Depressive Disorder/etiology Female Health Status Health Surveys Hepatitis C, Chronic/drug therapy/psychology Humans Male Quality of Life/psychology Questionnaires Severity of Illness Index Sickness Impact Profile Socioeconomic Factors Dewey 610 50 Section de médecine clinique 22 false 297 Etudes et traitement de l'hépatite C et B 554 Gut 57 11 bf112692-e47b-42a2-be33-a9a493af05c9 Article (Accepted version) Restricted Article.pdf 249310 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique

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