Background. Clinical failure of dental ceramics is usually reported as partial fracture of therestoration (chipping) or as catastrophic fracture of the whole structure. In contrast to met-als, ceramics are linear-elastic, brittle materials exhibiting extremely low damage toleranceto failure. Well documented clinical and lab reports have shown this fracture event oftenoccurs at loads far below their fracture strength due to intrinsic fatigue degradation via slowcrack growth or cyclic fatigue mechanisms. The presence and development of surface flawshave a dominant role in damage accumulation and lifetime reduction of ceramic structures.Aims. This ADM guidance document aims to summarize the aspects related to fatigue degra-dation of dental ceramics, reviewing the concepts of fatigue testing and furthermore aimsto provide practical guidance to young scientists entering into fatigue related research.The description of fatigue strength is always accompanied by a clear understanding of theunderlying fracture mechanisms.