Scientific article
OA Policy
English

Predictors for improvement of problem-solving during cognitive remediation for patients with Schizophrenia

Published inJournal of the International Neuropsychological Society, vol. 20, no. 4, p. 455-460
Publication date2014
Abstract

Cognitive remediation is a promising pathway for ameliorating cognitive impairment of patients with schizophrenia. Here, we investigate predictors of improvement in problem-solving ability for two different types of cognitive remediation - specific problem-solving training and training of basic cognition. For this purpose we conducted a re-analysis of a randomized controlled trial comparing these two training approaches. The main outcome measure was improvement in problem-solving performance. Correlational analyses were used to assess the contribution of clinical, cognitive and training-related predictors. In the problem-solving training group, impaired pre-training planning ability was associated with stronger improvement. In contrast, in the basic cognition training group antipsychotic medication dose emerged as a negative predictor. These results demonstrate that predictors for successful cognitive remediation depend on the specific intervention. Furthermore, our results suggest that at least in the planning domain patients with impaired performance benefit particularly from a specific intervention.

Keywords
  • Adult
  • Antipsychotic Agents/therapeutic use
  • Chlorpromazine/therapeutic use
  • Cognition Disorders/etiology/rehabilitation
  • Cognitive Therapy/methods
  • Female
  • Humans
  • Male
  • Neuropsychological Tests
  • Predictive Value of Tests
  • Problem Solving/drug effects/physiology
  • Psychiatric Status Rating Scales
  • Schizophrenia/complications/drug therapy
  • Single-Blind Method
  • Young Adult
Affiliation entities Not a UNIGE publication
Citation (ISO format)
RODEWALD, Katlehn et al. Predictors for improvement of problem-solving during cognitive remediation for patients with Schizophrenia. In: Journal of the International Neuropsychological Society, 2014, vol. 20, n° 4, p. 455–460. doi: 10.1017/S1355617714000162
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
Journal ISSN1355-6177
446views
255downloads

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