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Title

Dependence of position-effect variegation in Drosophila on dose of a gene encoding an unusual zinc-finger protein

Authors
Reuter, Gunter
Giarre, Marianna
Farah, Joseph
Gausz, Janos
Spierer, Anne
Published in Nature. 1990, vol. 344, no. 6263, p. 219-23
Abstract Position-effect variegation is the inactivation in some cells of a gene translocated next to heterochromatin, the region of the chromosome that is permanently condensed. The number of copies of the Drosophila gene Suvar(3)7 is a dose-limiting factor in this phenomenon, and seems from its sequence that it encodes a protein with five widely spaced zinc-fingers. This novel arrangement of zinc-fingers could help in packaging the chromatin fibre into heterochromatin, and also reflect a novel method of controlling the expression from DNA domains.
Keywords Amino Acid SequenceAnimalsBase SequenceCloning, MolecularDNA/geneticsDNA-Binding Proteins/geneticsDosage Compensation, GeneticDrosophila/geneticsHeterochromatinMetalloproteins/geneticsMolecular Sequence DataMutationPhosphorylationPigmentation/geneticsRestriction MappingSuppression, Genetic
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PMID: 2107402
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REUTER, Gunter et al. Dependence of position-effect variegation in Drosophila on dose of a gene encoding an unusual zinc-finger protein. In: Nature, 1990, vol. 344, n° 6263, p. 219-23. https://archive-ouverte.unige.ch/unige:9867

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Deposited on : 2010-08-06

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