Dependence of position-effect variegation in Drosophila on dose of a gene encoding an unusual zinc-finger protein
|Published in||Nature. 1990, vol. 344, no. 6263, p. 219-23|
|Abstract||Position-effect variegation is the inactivation in some cells of a gene translocated next to heterochromatin, the region of the chromosome that is permanently condensed. The number of copies of the Drosophila gene Suvar(3)7 is a dose-limiting factor in this phenomenon, and seems from its sequence that it encodes a protein with five widely spaced zinc-fingers. This novel arrangement of zinc-fingers could help in packaging the chromatin fibre into heterochromatin, and also reflect a novel method of controlling the expression from DNA domains.|
|Keywords||Amino Acid Sequence — Animals — Base Sequence — Cloning, Molecular — DNA/genetics — DNA-Binding Proteins/genetics — Dosage Compensation, Genetic — Drosophila/genetics — Heterochromatin — Metalloproteins/genetics — Molecular Sequence Data — Mutation — Phosphorylation — Pigmentation/genetics — Restriction Mapping — Suppression, Genetic|
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|REUTER, Gunter et al. Dependence of position-effect variegation in Drosophila on dose of a gene encoding an unusual zinc-finger protein. In: Nature, 1990, vol. 344, n° 6263, p. 219-23. https://archive-ouverte.unige.ch/unige:9867|