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Title

Subthalamic nucleus stimulation for Parkinson's disease preferentially improves akinesia of proximal arm movements compared to finger movements

Authors
Wenzelburger, Roland
Kopper, Florian
Zhang, Bao-Rong
Witt, Karsten
Hamel, Wolfgang
Weinert, Dieter
Kuhtz-Buschbeck, Johann
Golge, Mukaddes
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Published in Movement Disorders. 2003, vol. 18, no. 10, p. 1162-1169
Abstract Deep brain stimulation of the subthalamic nucleus (STN-DBS) reduces akinesia in Parkinson's disease but its impact on fine motor functions was unknown. We assessed the effects of DBS and a levodopa (L-dopa) test on the timing of the precision grip in 18 patients. Improvement on UPDRS-items reflecting hand functions and the shortening of the first phases of the precision grip were more distinct in the L-dopa test than in the pure STN-DBS condition. Other akinesia items and the time for build-up of lifting force were equally improved in both conditions. This suggests that routine STN-DBS might not be equally effective on all aspects of fine motor functions.
Keywords Antiparkinson Agents/therapeutic useArm/*physiopathologyDyskinesias/etiology/*therapyFingers/*physiopathologyHand StrengthHumansLevodopa/therapeutic useMovement/radiation effectsParkinson Disease/complications/*therapySubthalamic Nucleus/physiopathology/*radiation effectsTime Factors
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PMID: 14534921
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WENZELBURGER, Roland et al. Subthalamic nucleus stimulation for Parkinson's disease preferentially improves akinesia of proximal arm movements compared to finger movements. In: Movement Disorders, 2003, vol. 18, n° 10, p. 1162-1169. https://archive-ouverte.unige.ch/unige:95887

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Deposited on : 2017-08-04

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