Antioxidants, quinone reductase inducers and acetylcholinesterase inhibitors from Spondias tuberosa fruits

Zeraik, Maria Luiza; Ferreira Queiroz, Emerson; Marcourt, Laurence; Ciclet, Olivier; Castro-Gamboa, Ian; Silva, Dulce Helena Siqueira; Cuendet, Muriel; da Silva Bolzani, Vanderlan; Wolfender, Jean-Luc

doi:10.1016/j.jff.2015.12.009

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Title		Antioxidants, quinone reductase inducers and acetylcholinesterase inhibitors from Spondias tuberosa fruits
Authors		Zeraik, Maria Luiza Ferreira Queiroz, Emerson Marcourt, Laurence Ciclet, Olivier Castro-Gamboa, Ian Silva, Dulce Helena Siqueira Cuendet, Muriel da Silva Bolzani, Vanderlan Wolfender, Jean-Luc show all authors [1 - 9]
Published in		Journal of functional foods. 2016, vol. 21, p. 396-405
Abstract		The methanolic extract of umbu (Spondias tuberosa) presented high antioxidant activities in the DPPH, ABTS and ORAC assays, as well as acetylcholinesterase (AChE) inhibition activity. The dichloromethane extract exhibited cancer chemopreventive activity, with a quinone reductase induction in Hepa1c1c7 cells. The localization of the active compounds was performed by HPLC activity-based profiling, and preliminary structural information was obtained by HPLC-PAD-ESI-MS and UHPLC-TOF-HRMS. The main constituents from the methanolic extract were efficiently isolated in a single step by preparative MPLC-UV. Two new natural products were identified, together with five known compounds. The structures of the compounds were elucidated by 2D NMR and ESI-HRMS. The dichloromethane extract was fractionated by SPE and by semi-preparative HPLC-UV-ELSD. Using this approach, one anacardic acid derivative was isolated. However, this compound was not responsible for QR induction. This study highlights the potential of umbu as an active ingredient for functional food formulations.
Identifiers		DOI: 10.1016/j.jff.2015.12.009
Full text		Article (Published version) (729 Kb) - Limited access to UNIGE Other version: http://linkinghub.elsevier.com/retrieve/pii/S1756464615006131
Structures		Faculté des sciences / Section des sciences pharmaceutiques
Research group		Phytochimie et produits naturels bioactifs
Citation (ISO format)		ZERAIK, Maria Luiza et al. Antioxidants, quinone reductase inducers and acetylcholinesterase inhibitors from Spondias tuberosa fruits. In: Journal of functional foods, 2016, vol. 21, p. 396-405. doi: 10.1016/j.jff.2015.12.009 https://archive-ouverte.unige.ch/unige:94963