• Home
  1. Home
  2. Typhusepidemiologie in der Schweiz 1980-1983. Geringe oder fehlende Wirksamkeit des Lebendimpfstoffes Vivotif bei Tropenreisenden
Scientific article
German

Typhusepidemiologie in der Schweiz 1980-1983. Geringe oder fehlende Wirksamkeit des Lebendimpfstoffes Vivotif bei Tropenreisenden

Contributors

Wuthrich, R. P.; Somaini, B.; Steffen, R.; Hirschel, Bernard

Published in

Schweizerische medizinische Wochenschrift, vol. 115, no. 48, p. 1714-1720

Publication date

1985

Abstract

214 cases of typhoid fever (TF) occurring in Switzerland between January 1980 and December 1984 were analyzed for travel history, vaccine status and nationality. A subgroup of Swiss tourists who acquired TF in India was compared to a sample of healthy Swiss tourists who travelled to India in 1983 to determine the factors predisposing to TF. Eighty cases of TF occurred in Swiss tourists to the Third World, of whom 26 had travelled in India. Among the latter, the length of stay was longer than in the control sample of 258 healthy tourists, and "trekking" (travelling off the usual tourist routes with backpacking) was more frequent. 20 of the 80 patients had been vaccinated with the live oral typhoid vaccine Vivotif (strain S. typhi Ty 21a, contained in gelatine capsules, to be taken with bicarbonate capsules), marketed in Switzerland in 1981-1984. Comparison of the vaccination rates in case and control groups indicated that the vaccine efficacy was not significantly different from 0% during the time of observation. This lack of efficacy may be related to inadequate dosage and to the lack of stability of the vaccine. Forty cases of TF occurred in Swiss who had travelled in European countries, of whom 8 had not travelled outside Switzerland. The remaining 94 cases occurred in non-Swiss travellers, a majority of whom were from Mediterranean countries. TF in Switzerland was associated with a history of travel in 96% of cases. The live oral typhoid vaccine Vivotif was ineffective between 1981 and 1983.

Keywords

  • Carrier State
  • Humans
  • Risk
  • Switzerland
  • Travel
  • Typhoid Fever/epidemiology/ prevention & control
  • Typhoid-Paratyphoid Vaccines/ administration & dosage

UNIGE affiliation entities

Citation (ISO format)

WUTHRICH, R. P. et al. Typhusepidemiologie in der Schweiz 1980-1983. Geringe oder fehlende Wirksamkeit des Lebendimpfstoffes Vivotif bei Tropenreisenden. In: Schweizerische medizinische Wochenschrift, 1985, vol. 115, n° 48, p. 1714–1720.

Identifiers

Journal ISSN

0036-7672
527views
0downloads

Technical informations

Creation

12/07/2010 14:37:24

First validation

12/07/2010 14:37:24

Update

14/03/2023 15:54:49

Status update

14/03/2023 15:54:49

Last indexation

29/10/2024 16:08:58
All rights reserved by Archive ouverte UNIGE and the University of Geneva
OpenAIRE Indexed & Validated