Scientific article
Open access

Interferon-driven deletion of antiviral B cells at the onset of chronic infection

Published inScience immunology, vol. 1, no. 4
Publication date2016

Inadequate antibody responses and perturbed B cell compartments represent hallmarks of persistent microbial infections, but the mechanisms whereby persisting pathogens suppress humoral immunity remain poorly defined. Using adoptive transfer experiments in the context of a chronic lymphocytic choriomeningitis virus (LCMV) infection of mice, we have documented rapid depletion of virus-specific B cells that coincided with the early type I interferon response to infection. We found that the loss of activated B cells was driven by type I interferon (IFN-I) signaling to several cell types including dendritic cells, T cells and myeloid cells. Intriguingly, this process was independent of B cell-intrinsic IFN-I sensing and resulted from biased differentiation of naïve B cells into short-lived antibody-secreting cells. The ability to generate robust B cell responses was restored upon IFN-I receptor blockade or, partially, when experimentally depleting myeloid cells or the IFN-I-induced cytokines interleukin 10 and tumor necrosis factor alpha. We have termed this IFN-I-driven depletion of B cells "B cell decimation". Strategies to counter "B cell decimation" should thus help us better leverage humoral immunity in the combat against persistent microbial diseases.

Citation (ISO format)
FALLET, Benedict et al. Interferon-driven deletion of antiviral B cells at the onset of chronic infection. In: Science immunology, 2016, vol. 1, n° 4. doi: 10.1126/sciimmunol.aah6817
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Article (Accepted version)
ISSN of the journal2470-9468

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