Weighted Genetic Risk Scores and Prediction of Weight Gain in Solid Organ Transplant Populations

Saigi-Morgui, Núria; Quteineh, Lina; Bochud, Pierre-Yves; Crettol, Séverine; Kutalik, Zoltán; Wojtowicz, Agnieszka; Bibert, Stéphanie; Beckmann, Sonja; Mueller, Nicolas J; Binet, Isabelle; Van Delden, Christian; Steiger, Jürg; Mohacsi, Paul; Stirnimann, Guido; Gasche-Soccal, Paola Marina Alessandra; Pascual, Manuel; Eap, Chin B

doi:10.1371/journal.pone.0164443

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Title		Weighted Genetic Risk Scores and Prediction of Weight Gain in Solid Organ Transplant Populations
Authors		Saigi-Morgui, Núria Quteineh, Lina Bochud, Pierre-Yves Crettol, Séverine Kutalik, Zoltán Wojtowicz, Agnieszka Bibert, Stéphanie Beckmann, Sonja Mueller, Nicolas J Binet, Isabelle Van Delden, Christian Steiger, Jürg Mohacsi, Paul Stirnimann, Guido Gasche-Soccal, Paola Marina Alessandra Pascual, Manuel Eap, Chin B show all authors [1 - 17]
Published in		PLOS ONE. 2016, vol. 11, no. 10, p. e0164443
Abstract		Polygenic obesity in Solid Organ Transplant (SOT) populations is considered a risk factor for the development of metabolic abnormalities and graft survival. Few studies to date have studied the genetics of weight gain in SOT recipients. We aimed to determine whether weighted genetic risk scores (w-GRS) integrating genetic polymorphisms from GWAS studies (SNP group#1 and SNP group#2) and from Candidate Gene studies (SNP group#3) influence BMI in SOT populations and if they predict ≥10% weight gain (WG) one year after transplantation. To do so, two samples (nA = 995, nB = 156) were obtained from naturalistic studies and three w-GRS were constructed and tested for association with BMI over time. Prediction of 10% WG at one year after transplantation was assessed with models containing genetic and clinical factors.
Identifiers		DOI: 10.1371/journal.pone.0164443 PMID: 27788139
Full text		Article (Published version) (1.2 MB) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de chirurgie Faculté de médecine / Section de médecine fondamentale / Département de médecine génétique et développement
Research groups		Transplantation et hépatologie (905) Groupe Gasche-Soccal Paola (958) Quorom-sensing et gènes de virulence (301)
Citation (ISO format)		SAIGI-MORGUI, Núria et al. Weighted Genetic Risk Scores and Prediction of Weight Gain in Solid Organ Transplant Populations. In: PLOS ONE, 2016, vol. 11, n° 10, p. e0164443. doi: 10.1371/journal.pone.0164443 https://archive-ouverte.unige.ch/unige:93781