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Weighted Genetic Risk Scores and Prediction of Weight Gain in Solid Organ Transplant Populations

Published inPloS one, vol. 11, no. 10, e0164443
Publication date2016
Abstract

Polygenic obesity in Solid Organ Transplant (SOT) populations is considered a risk factor for the development of metabolic abnormalities and graft survival. Few studies to date have studied the genetics of weight gain in SOT recipients. We aimed to determine whether weighted genetic risk scores (w-GRS) integrating genetic polymorphisms from GWAS studies (SNP group#1 and SNP group#2) and from Candidate Gene studies (SNP group#3) influence BMI in SOT populations and if they predict ≥10% weight gain (WG) one year after transplantation. To do so, two samples (nA = 995, nB = 156) were obtained from naturalistic studies and three w-GRS were constructed and tested for association with BMI over time. Prediction of 10% WG at one year after transplantation was assessed with models containing genetic and clinical factors.

Citation (ISO format)
SAIGI-MORGUI, Núria et al. Weighted Genetic Risk Scores and Prediction of Weight Gain in Solid Organ Transplant Populations. In: PloS one, 2016, vol. 11, n° 10, p. e0164443. doi: 10.1371/journal.pone.0164443
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ISSN of the journal1932-6203
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