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Weighted Genetic Risk Scores and Prediction of Weight Gain in Solid Organ Transplant Populations

Saigi-Morgui, Núria
Kutalik, Zoltán
Wojtowicz, Agnieszka
Beckmann, Sonja
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Published in PloS one. 2016, vol. 11, no. 10, e0164443
Abstract Polygenic obesity in Solid Organ Transplant (SOT) populations is considered a risk factor for the development of metabolic abnormalities and graft survival. Few studies to date have studied the genetics of weight gain in SOT recipients. We aimed to determine whether weighted genetic risk scores (w-GRS) integrating genetic polymorphisms from GWAS studies (SNP group#1 and SNP group#2) and from Candidate Gene studies (SNP group#3) influence BMI in SOT populations and if they predict ≥10% weight gain (WG) one year after transplantation. To do so, two samples (nA = 995, nB = 156) were obtained from naturalistic studies and three w-GRS were constructed and tested for association with BMI over time. Prediction of 10% WG at one year after transplantation was assessed with models containing genetic and clinical factors.
PMID: 27788139
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Research groups Groupe Gasche-Soccal Paola (958)
Quorom-sensing et gènes de virulence (301)
Transplantation et hépatologie (905)
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SAIGI-MORGUI, Núria et al. Weighted Genetic Risk Scores and Prediction of Weight Gain in Solid Organ Transplant Populations. In: PloS one, 2016, vol. 11, n° 10, p. e0164443. doi: 10.1371/journal.pone.0164443 https://archive-ouverte.unige.ch/unige:93781

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Deposited on : 2017-04-21

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