Scientific article

18F-FDG and 68Ga-DOTATATE PET/CT in von Hippel-Lindau Disease-Associated Retinal Hemangioblastoma

Published inClinical nuclear medicine, vol. 42, no. 3, p. 189-190
Publication date2017

Retinal hemangioblastomas are highly vascular benign tumors that can be encountered either sporadically or within the von Hippel-Lindau (VHL) syndrome. We report a case of a VHL patient with retinal hemangioblastoma who underwent PET/CT scans using F-FDG and Ga-DOTATATE. The tumor showed low-level F-FDG and increased Ga-DOTATATE activity, suggesting cell-surface overexpression of somatostatin receptors. The presented case indicates the clinical applications of somatostatin receptor imaging with Ga-DOTA-conjugated peptides in detection and follow-up of VHL manifestations, screening of asymptomatic gene carriers, and in diagnosis of sporadic retinal hemangioblastomas, which may have similar features on MRI with other retinal tumors.

  • Adult
  • Fluorodeoxyglucose F18
  • Gallium Radioisotopes
  • Hemangioblastoma/diagnostic imaging/metabolism
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Organometallic Compounds
  • Positron Emission Tomography Computed Tomography
  • Radiopharmaceuticals
  • Receptors, Somatostatin/metabolism
  • Retinal Neoplasms/diagnostic imaging/metabolism
  • von Hippel-Lindau Disease/diagnostic imaging/genetics/metabolism
Citation (ISO format)
PAPADAKIS, Georgios Z et al. 18F-FDG and 68Ga-DOTATATE PET/CT in von Hippel-Lindau Disease-Associated Retinal Hemangioblastoma. In: Clinical nuclear medicine, 2017, vol. 42, n° 3, p. 189–190. doi: 10.1097/RLU.0000000000001511
Main files (1)
Article (Published version)
ISSN of the journal0363-9762

Technical informations

Creation03/02/2017 12:10:00 PM
First validation03/02/2017 12:10:00 PM
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