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18F-FDG and 68Ga-DOTATATE PET/CT in von Hippel-Lindau Disease-Associated Retinal Hemangioblastoma

Papadakis, Georgios Z
Millo, Corina
Jassel, Inderbir S
Bagci, Ulas
Karantanas, Apostolos H
Patronas, Nicholas
Published in Clinical Nuclear Medicine. 2017, vol. 42, no. 3, p. 189-190
Abstract Retinal hemangioblastomas are highly vascular benign tumors that can be encountered either sporadically or within the von Hippel-Lindau (VHL) syndrome. We report a case of a VHL patient with retinal hemangioblastoma who underwent PET/CT scans using F-FDG and Ga-DOTATATE. The tumor showed low-level F-FDG and increased Ga-DOTATATE activity, suggesting cell-surface overexpression of somatostatin receptors. The presented case indicates the clinical applications of somatostatin receptor imaging with Ga-DOTA-conjugated peptides in detection and follow-up of VHL manifestations, screening of asymptomatic gene carriers, and in diagnosis of sporadic retinal hemangioblastomas, which may have similar features on MRI with other retinal tumors.
Keywords AdultFluorodeoxyglucose F18Gallium RadioisotopesHemangioblastoma/diagnostic imaging/metabolismHumansMagnetic Resonance ImagingMaleOrganometallic CompoundsPositron Emission Tomography Computed TomographyRadiopharmaceuticalsReceptors, Somatostatin/metabolismRetinal Neoplasms/diagnostic imaging/metabolismvon Hippel-Lindau Disease/diagnostic imaging/genetics/metabolism
PMID: 28033220
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Research group Cancer du poumon et mésothéliome pleural malin (944)
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PAPADAKIS, Georgios Z et al. 18F-FDG and 68Ga-DOTATATE PET/CT in von Hippel-Lindau Disease-Associated Retinal Hemangioblastoma. In: Clinical Nuclear Medicine, 2017, vol. 42, n° 3, p. 189-190. doi: 10.1097/RLU.0000000000001511 https://archive-ouverte.unige.ch/unige:93697

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Deposited on : 2017-04-21

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