Kinetics of Cardiac Output at the Onset of Exercise in Precapillary Pulmonary Hypertension

Lador, Frédéric; Bringard, Aurélien; Bengueddache, Samir; Ferretti, Guido; Bendjelid, Karim; Gasche-Soccal, Paola Marina Alessandra; Noble, Stéphane Laurent; Beghetti, Maurice; Chemla, Denis; Hervé, Philippe; Sitbon, Olivier

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Title		Kinetics of Cardiac Output at the Onset of Exercise in Precapillary Pulmonary Hypertension
Authors		Lador, Frédéric Bringard, Aurélien Bengueddache, Samir Ferretti, Guido Bendjelid, Karim Gasche-Soccal, Paola Marina Alessandra Noble, Stéphane Laurent Beghetti, Maurice Chemla, Denis Hervé, Philippe Sitbon, Olivier show all authors [1 - 11]
Published in		BioMed Research International. 2016, vol. 2016, p. 6050193
Abstract		Purpose. Cardiac output (CO) is a cornerstone parameter in precapillary pulmonary hypertension (PH). The Modelflow (MF) method offers a reliable noninvasive determination of its beat-by-beat changes. So MF allows exploration of CO adjustment with the best temporal resolution. Methods. Fifteen subjects (5 PH patients, 10 healthy controls) performed a submaximal supine exercise on a cycle ergometer after 5 min of rest. CO was continuously determined by MF (COMF). Kinetics of heart rate (HR), stroke volume (SV), and CO were determined with 3 monoexponential models. Results. In PH patients, we observed a sudden and transitory drop of SV upon exercise onset. This implied a transitory drop of CO whose adjustment to a new steady state depended on HR increase. The kinetics of HR and CO for PH patients was slower than that of controls for all models and for SV in model 1. SV kinetics was faster for PH patients in models 2 and 3. Conclusion. This is the first description of beat-by-beat cardiovascular adjustments upon exercise onset in PH. The kinetics of HR and CO appeared slower than those of healthy controls and there was a transitory drop of CO upon exercise onset in PH due to a sudden drop of SV.
Identifiers		DOI: 10.1155/2016/6050193 PMID: 27990432
Full text		Article (Published version) (1.4 MB) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine interne des spécialités Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie et soins intensifs Faculté de médecine / Section de médecine clinique / Département de pédiatrie
Research groups		L'hypertension pulmonaire (pédiatrie) (228) Groupe de recherche en hémodynamique (913)
Citation (ISO format)		LADOR, Frédéric et al. Kinetics of Cardiac Output at the Onset of Exercise in Precapillary Pulmonary Hypertension. In: BioMed Research International, 2016, vol. 2016, p. 6050193. https://archive-ouverte.unige.ch/unige:93329