en
Scientific article
English

In-vitro and in-vivo evaluation of the antistaphylococcal activity of S-5556, a new 16-membered macrolide

Published inThe journal of antimicrobial chemotherapy, vol. 30, no. 3, p. 327-337
Publication date1992
Abstract

During recent years, a resurgence of interest in the macrolides had led to the discovery of new derivatives of erythromycin with improved antibacterial activity and pharmacokinetic properties. In this study the in-vitro and in-vivo antistaphylococcal activity of S-5556, a 16-membered macrolide, was evaluated. In vitro, S-5556 was slightly less active than erythromycin against methicillin-susceptible Staphylococcus aureus. In contrast, it had superior activity for methicillin-resistant S. aureus (MRSA); several of these strains with inducible resistance to the macrolides-lincosamides-streptogramins group were susceptible to S-5556 whereas erythromycin was inactive. The combination of S-5556 with oxacillin was synergic for most MRSA strains tested. In vivo, a single prophylactic dose of S-5556 prevented 75%-100% of the cases of acute staphylococcal subcutaneous foreign body infection in a guinea pig-model. In a rat-model of chronic implant infection due to a methicillin- and erythromycin-resistant S. aureus strain, S-5556 significantly decreased the bacterial concentration around the foreign material, however resistant mutants emerged.

Keywords
  • Animals
  • Anti-Bacterial Agents/ pharmacology
  • Coagulase/analysis
  • Disease Models, Animal
  • Drug Synergism
  • Foreign Bodies/complications
  • Guinea Pigs
  • Methicillin Resistance
  • Microbial Sensitivity Tests
  • Rats
  • Skin
  • Species Specificity
  • Staphylococcal Skin Infections/prevention & control
  • Staphylococcus aureus/ drug effects/enzymology
  • Tylosin/ analogs & derivatives/pharmacology
Citation (ISO format)
CHUARD, C. et al. In-vitro and in-vivo evaluation of the antistaphylococcal activity of S-5556, a new 16-membered macrolide. In: The journal of antimicrobial chemotherapy, 1992, vol. 30, n° 3, p. 327–337. doi: 10.1093/jac/30.3.327
Identifiers
ISSN of the journal0305-7453
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