UNIGE document Scientific Article
previous document  unige:92897  next document
add to browser collection
Title

Perivascular medical devices and drug delivery systems: Making the right choices

Authors
Saucy, François
Haefliger, Jacques-Antoine
Published in Biomaterials. 2017, vol. 128, p. 56-68
Abstract Perivascular medical devices and perivascular drug delivery systems are conceived for local application around a blood vessel during open vascular surgery. These systems provide mechanical support and/or pharmacological activity for the prevention of intimal hyperplasia following vessel injury. Despite abundant reports in the literature and numerous clinical trials, no efficient perivascular treatment is available. In this review, the existing perivascular medical devices and perivascular drug delivery systems, such as polymeric gels,meshes, sheaths, wraps, matrices, and metal meshes, are jointly evaluated. The key criteria for the design of an ideal perivascular system are identified. Perivascular treatments should have mechanical specifications that ensure system localization, prolonged retention and adequate vascular constriction. From the data gathered, it appears that a drug is necessary to increase the efficacy of these systems. As such, the release kinetics of pharmacological agents should match the development of the pathology. A successful perivascular system must combine these optimized pharmacological and mechanical properties to be efficient.
Keywords Perivascular administrationPeriadventitial administrationIntimal hyperplasiaWrapMeshCuff
Identifiers
PMID: 28288349
Full text
Structures
Research groups Technologie pharmaceutique
Biopharmacie
Citation
(ISO format)
MYLONAKI, Ioanna et al. Perivascular medical devices and drug delivery systems: Making the right choices. In: Biomaterials, 2017, vol. 128, p. 56-68. doi: 10.1016/j.biomaterials.2017.02.028 https://archive-ouverte.unige.ch/unige:92897

435 hits

247 downloads

Update

Deposited on : 2017-03-29

Export document
Format :
Citation style :