UNIGE document Scientific Article
previous document  unige:9170  next document
add to browser collection

Common genetic variation and the control of HIV-1 in humans

Fellay, Jacques
Ge, Dongliang
CollaborationWith : Descombes, Patrick / Antonarakis, Stylianos
Published in PLOS genetics. 2009, vol. 5, no. 12, e1000791
Abstract To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians.
Keywords AdultAllelesDisease ProgressionFemaleGenetic VariationGenotypeHIV Infections/virologyHIV-1/ physiologyHumansKaplan-Meiers EstimateMajor Histocompatibility Complex/geneticsMalePhenotypePolymorphism, Single Nucleotide/geneticsViral Load
PMID: 20041166
Full text
(ISO format)
FELLAY, Jacques, GE, Dongliang. Common genetic variation and the control of HIV-1 in humans. In: PLOS genetics, 2009, vol. 5, n° 12, p. e1000791. doi: 10.1371/journal.pgen.1000791 https://archive-ouverte.unige.ch/unige:9170

1093 hits



Deposited on : 2010-07-12

Export document
Format :
Citation style :