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Scientific article
English

Receptor-mediated phagocytosis by macrophages induces a calcium-dependent transient increase in c-fos transcription

Published inOncogene, vol. 4, no. 2, p. 237-241
Publication date1989
Abstract

The transcription of the c-fos gene and the level of c-fos mRNA in mouse peritoneal macrophages are rapidly, strongly and transiently increased after Fc- and C3b-mediated phagocytosis, but not after phagocytosis of latex particles. In order to induce both phagocytosis and a rise in c-fos mRNA, binding to receptors must be followed by mobilization of Ca++ from intracellular Induction of c-fos transcription in macrophages by other agents acting through different intracellular "messengers', i.e. phorbol esters (protein kinase C), cholera toxin (cAMP) and dexamethasone (glucocorticoid receptor) also depends on intracellular Ca++. In all these conditions, induction of c-fos transcription is inhibited by the calmodulin antagonist W7, suggesting a common Ca++-dependent pathway for c-fos gene activation in macrophages.

Keywords
  • Animals
  • Calcium/ physiology
  • Macrophages/ immunology
  • Mice
  • Mice, Inbred C3H
  • Phagocytosis
  • Proto-Oncogene Proteins/ genetics
  • Proto-Oncogene Proteins c-fos
  • RNA, Messenger/analysis
  • Receptors, Cell Surface/physiology
  • Tetradecanoylphorbol Acetate/pharmacology
  • Transcription, Genetic
Citation (ISO format)
COLLART, Martine et al. Receptor-mediated phagocytosis by macrophages induces a calcium-dependent transient increase in c-fos transcription. In: Oncogene, 1989, vol. 4, n° 2, p. 237–241.
Identifiers
ISSN of the journal0950-9232
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