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Blood volume and haemoglobin oxygen content changes in human bone marrow during orthostatic stress

Leung, Terence S
Courvoisier, Celine
Giust, Remo
Tribillon, Gilbert
Gharbi, Tijani
Delpy, David T
Published in Journal of Physiological Anthropology. 2006, vol. 25, no. 1, p. 1-6
Abstract The interest in, and the need for effective measures to be used in screening, diagnosis, and the follow-up of skeletal pathologies is growing markedly. This paper proposes a completely new and non-invasive technique allowing the study of the human tibia bone marrow (BM) haemodynamics with a time resolution of 1 s. The technique, based on near infrared spectroscopy, is sensitive enough to allow the detection of BM blood volume and/or oxygen saturation changes during orthostatic variations imposed by a tilt bed. An increase in the slope of the bed of 15 degrees is sufficient to detect this phenomenon. The ability to study the possible presence of a neural control of BM haemodynamics is also discussed. No other existing technique currently allows one to obtain the proposed results and this approach might open up a new field of study related to human BM physiology.
Keywords AdultBlood VolumeBone Marrow/metabolismHemoglobins/metabolismHumansHypotension, Orthostatic/metabolism/physiopathologyOxygen/metabolismSpectroscopy, Near-InfraredStress, Physiological/metabolism/physiopathology
PMID: 16617202
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Research group Groupe Binzoni Tiziano (radiologie) (234)
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BINZONI, Tiziano et al. Blood volume and haemoglobin oxygen content changes in human bone marrow during orthostatic stress. In: Journal of Physiological Anthropology, 2006, vol. 25, n° 1, p. 1-6. https://archive-ouverte.unige.ch/unige:91045

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Deposited on : 2017-01-13

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