Direct cell-to-cell transmission of vesicular stomatitis virus

Vassalli, Jean-Dominique; Lombardi, Tommaso; Wohlwend, Annelise Isabelle; Montesano, Roberto; Orci, Lelio

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Title		Direct cell-to-cell transmission of vesicular stomatitis virus
Authors		Vassalli, Jean-Dominique Lombardi, Tommaso Wohlwend, Annelise Isabelle Montesano, Roberto Orci, Lelio
Published in		Journal of Cell Science. 1986, vol. 85, p. 125-131
Abstract		Vesicular stomatitis virus (VSV) infection of kidney-derived, LLC-PK1 epithelial cells resulted in the budding of new viral particles into the basolateral space of the cultures. In lateral regions where cells were in close apposition, the majority of assembling viral particles in the process of budding from the producing cell had their apex already engaged in clathrin-coated pits of the neighbouring cell surface. These observations suggest that the viral envelope-plasma membrane interaction triggers the focal formation of clathrin-coated pits; they also show how VSV infection could spread throughout a tissue with only minimal exposure to a host's extracellular environment.
Keywords		Animals — Cell Line — Coated Pits, Cell-Membrane/microbiology — Kidney/microbiology — Microscopy, Electron — Swine — Vesicular stomatitis Indiana virus/ physiology
Identifiers		PMID: 3025232
Full text		Article - Free access Other version: http://jcs.biologists.org/cgi/reprint/85/1/125.pdf
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine
Citation (ISO format)		VASSALLI, Jean-Dominique et al. Direct cell-to-cell transmission of vesicular stomatitis virus. In: Journal of Cell Science, 1986, vol. 85, p. 125-131. https://archive-ouverte.unige.ch/unige:9071