Scientific article
Open access

Direct cell-to-cell transmission of vesicular stomatitis virus

Published inJournal of cell science, vol. 85, p. 125-131
Publication date1986

Vesicular stomatitis virus (VSV) infection of kidney-derived, LLC-PK1 epithelial cells resulted in the budding of new viral particles into the basolateral space of the cultures. In lateral regions where cells were in close apposition, the majority of assembling viral particles in the process of budding from the producing cell had their apex already engaged in clathrin-coated pits of the neighbouring cell surface. These observations suggest that the viral envelope-plasma membrane interaction triggers the focal formation of clathrin-coated pits; they also show how VSV infection could spread throughout a tissue with only minimal exposure to a host's extracellular environment.

  • Animals
  • Cell Line
  • Coated Pits, Cell-Membrane/microbiology
  • Kidney/microbiology
  • Microscopy, Electron
  • Swine
  • Vesicular stomatitis Indiana virus/ physiology
Citation (ISO format)
VASSALLI, Jean-Dominique et al. Direct cell-to-cell transmission of vesicular stomatitis virus. In: Journal of cell science, 1986, vol. 85, p. 125–131.
Main files (1)
ISSN of the journal0021-9533

Technical informations

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