Handling trial participants with missing outcome data when conducting a meta-analysis: a systematic survey of proposed approaches

Akl, Elie A; Kahale, Lara A; Agoritsas, Thomas; Brignardello-Petersen, Romina; Busse, Jason W; Carrasco-Labra, Alonso; Ebrahim, Shanil; Johnston, Bradley C; Neumann, Ignacio; Sola, Ivan; Sun, Xin; Vandvik, Per; Zhang, Yuqing; Alonso-Coello, Pablo; Guyatt, Gordon

doi:10.1186/s13643-015-0083-6

Scientific article

Review

English

Handling trial participants with missing outcome data when conducting a meta-analysis: a systematic survey of proposed approaches

ContributorsAkl, Elie A; Kahale, Lara A; Agoritsas, Thomas

; Brignardello-Petersen, Romina; Busse, Jason W; Carrasco-Labra, Alonso; Ebrahim, Shanil; Johnston, Bradley C; Neumann, Ignacio; Sola, Ivan; Sun, Xin; Vandvik, Per; Zhang, Yuqing; Alonso-Coello, Pablo; Guyatt, Gordon

Published inSystematic reviews, vol. 4, 98

Publication date2015

Abstract

When potentially associated with the likelihood of outcome, missing participant data represents a serious potential source of bias in randomized trials. Authors of systematic reviews frequently face this problem when conducting meta-analyses. The objective of this study is to conduct a systematic survey of the relevant literature to identify proposed approaches for how systematic review authors should handle missing participant data when conducting a meta-analysis.

Keywords

Bias (Epidemiology)
Data Accuracy
Humans
Meta-Analysis as Topic
Patient Dropouts
Research Design/statistics & numerical data
Surveys and Questionnaires

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de réadaptation et gériatrie

Research groups

Epidémiologie clinique (115)

Citation (ISO format)

AKL, Elie A et al. Handling trial participants with missing outcome data when conducting a meta-analysis: a systematic survey of proposed approaches. In: Systematic reviews, 2015, vol. 4, p. 98. doi: 10.1186/s13643-015-0083-6

Article (Published version)

Identifiers

PID : unige:90344
DOI : 10.1186/s13643-015-0083-6
PMID : 26202162

Journal ISSN2046-4053

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176downloads

Creation18/11/2016 10:31:00

First validation18/11/2016 10:31:00

Update time15/03/2023 01:10:33

Status update15/03/2023 01:10:32

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Handling trial participants with missing outcome data when conducting a meta-analysis: a systematic survey of proposed approaches

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