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Influences génétiques et environnementales sur la neuromodulation et l’effet antinociceptif du dextromethorphan

Oestreicher, M
Dayer, P
Published in Schweizerische medizinische Wochenschrift. 1998, vol. 128, no. 6, p. 212-215
Abstract Administration of NMDA antagonists leads to attenuation or disappearance of some symptoms of central sensitization, such as secondary hyperalgesia. However, the side effects of NMDA antagonists to a large extent counterbalance the expected benefits, thus preventing wide or prolonged use. Dextromethorphan and its metabolite dextrophan, on the other hand, are established and safe drugs. Experimentally they both antagonize the NMDA receptor. This study evaluates the effects of dextromethorphan and its metabolite in pain models using electrical stimulation for testing the antinociceptive effect and capsaicin-induced hyperalgesia. Dextromethorphan shows clear antinociceptive as well as neuromodulary effects, both depending heavily on the cytochrome P450 2D6 phenotype (CYP2D6).
Keywords AdultAnalgesics, Opioid/pharmacokinetics/pharmacologyAntitussive Agents/pharmacokinetics/pharmacologyDextromethorphan/pharmacokinetics/pharmacologyDouble-Blind MethodFemaleHumansMaleMetabolic Clearance Rate/geneticsN-Methylaspartate/antagonists & inhibitorsPain Threshold/drug effectsPhenotypeReceptors, N-Methyl-D-Aspartate/antagonists & inhibitorsRetrospective StudiesSocial Environment
PMID: 9540144
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Research group Groupe Desmeules Jules (pharmacologie/toxicologie) (567)
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OESTREICHER, M et al. Influences génétiques et environnementales sur la neuromodulation et l’effet antinociceptif du dextromethorphan. In: Schweizerische medizinische Wochenschrift, 1998, vol. 128, n° 6, p. 212-215. https://archive-ouverte.unige.ch/unige:90118

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