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Title

Increase in bone mineral density after successful parathyroidectomy for tertiary hyperparathyroidism after renal transplantation

Authors
Staub-Zähner, Tania
Clerici, Thomas
Marangon, Nicola
Binet, Isabelle
Myers, Patrick-Olivier
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Published in World Journal of Surgery. 2008, vol. 32, no. 8, p. 1795-801
Abstract BACKGROUND: Few studies have reported changes of bone mineral density (BMD) after parathyroidectomy in patients with persistent hyperparathyroidism after renal transplantation (3 HPT). PATIENTS AND METHODS: We retrospectively analyzed 14 patients who underwent successful parathyroidectomy for 3 HPT and who had available BMD data before and after parathyroidectomy. RESULTS: Median follow-up time was 26 months (IQR: 16.8-40.2). Serum calcium levels decreased significantly after parathyroidectomy (2.32 +/- 0.09 versus 2.66 +/- 0.16 mmol/l; p < 0.01), as did PTH levels (5.1 +/- 3.0 versus 27.8 +/- 23.7 pmol/l; p < 0.01). Nine patients (64%) had a steroid-free immunosuppression at follow-up. Mean increase in BMD was 9.5 +/- 8.0% for the spine and 9.5 +/- 7.9% for the hip (p < 0.01 for both sites). Patients with osteoporosis (T-score <or= 2.5) or osteopenia (T-score <or= 1) before parathyroidectomy had the biggest increase in BMD (10.7 +/- 7.7% in hip BMD and of 12.3 +/- 8.1% in spine BMD). CONCLUSIONS: Parathyroidectomy is an efficient treatment of osteoporosis and osteopenia in patients with 3 HPT.
Keywords Bone Density/physiologyFemaleHumansHyperparathyroidism/etiology/physiopathology/surgeryKidney TransplantationMaleMiddle AgedParathyroidectomyRetrospective StudiesTreatment Outcome
Identifiers
PMID: 18311499
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Research groups Groupe Pierre-Yves Martin (néphrologie) (30)
Nutrition et os (66)
Mésothéliome pleural malin (944)
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COLLAUD, Stéphane et al. Increase in bone mineral density after successful parathyroidectomy for tertiary hyperparathyroidism after renal transplantation. In: World Journal of Surgery, 2008, vol. 32, n° 8, p. 1795-801. https://archive-ouverte.unige.ch/unige:900

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Deposited on : 2009-02-23

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