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Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder

Hou, Liping
Bergen, Sarah E
Akula, Nirmala
Song, Jie
Hultman, Christina M
Landén, Mikael
CollaborationWith : Aubry, Jean-Michel / Dayer, Alexandre
Published in Human Molecular Genetics. 2016, vol. 25, no. 15, p. 3383-3394
Abstract Bipolar disorder (BD) is a genetically complex mental illness characterized by severe oscillations of mood and behaviour. Genome-wide association studies (GWAS) have identified several risk loci that together account for a small portion of the heritability. To identify additional risk loci, we performed a two-stage meta-analysis of >9 million genetic variants in 9,784 bipolar disorder patients and 30,471 controls, the largest GWAS of BD to date. In this study, to increase power we used ∼2,000 lithium-treated cases with a long-term diagnosis of BD from the Consortium on Lithium Genetics, excess controls, and analytic methods optimized for markers on the X-chromosome. In addition to four known loci, results revealed genome-wide significant associations at two novel loci: an intergenic region on 9p21.3 (rs12553324, P =  5.87 × 10 (-)  (9); odds ratio (OR) = 1.12) and markers within ERBB2 (rs2517959, P =  4.53 × 10 (-)  (9); OR = 1.13). No significant X-chromosome associations were detected and X-linked markers explained very little BD heritability. The results add to a growing list of common autosomal variants involved in BD and illustrate the power of comparing well-characterized cases to an excess of controls in GWAS.
PMID: 27329760
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Article (Published version) (483 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Research groups Thérapeutiques des Troubles de l'Humeur et Anxieux (689)
Groupe Dayer Alexandre (Formation du circuit cortical) (875)
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HOU, Liping et al. Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder. In: Human Molecular Genetics, 2016, vol. 25, n° 15, p. 3383-3394. doi: 10.1093/hmg/ddw181 https://archive-ouverte.unige.ch/unige:89910

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Deposited on : 2016-12-06

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