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Increased extracellular glutamate in rat prefrontal cortex: movement artifact contribution

Rossetti, Z L
Published in Brain Research. 2001, vol. 890, no. 1, p. 189-191
Abstract Extracellular glutamate levels were measured by microdialysis in the prefrontal cortex (PFC) of anaesthetised rats in response to a short, experimenter-provoked mechanical movement of the animal head. Movement caused significant, nerve impulse-independent elevations of glutamate levels (maximum increase, 300+/-30% of baseline). This study reveals a possible artifact in the measurement of extracellular glutamate concentrations by microdialysis and suggests that, in awake animals, treatments associated with stimulation of motor activity can cause non-specific efflux of glutamate in the PFC.
Keywords AnesthesiaAnimalsArousal/physiologyArtifactsExtracellular Space/metabolismGlutamic Acid/metabolismMaleMicrodialysis/standardsMotor Activity/physiologyMovement/physiologyPrefrontal Cortex/metabolismRatsRats, Sprague-Dawley
PMID: 11164783
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CARBONI, Sonia, ROSSETTI, Z L. Increased extracellular glutamate in rat prefrontal cortex: movement artifact contribution. In: Brain Research, 2001, vol. 890, n° 1, p. 189-191.

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Deposited on : 2016-12-06

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