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Scientific article
English

Increased extracellular glutamate in rat prefrontal cortex: movement artifact contribution

Published inBrain research, vol. 890, no. 1, p. 189-191
Publication date2001
Abstract

Extracellular glutamate levels were measured by microdialysis in the prefrontal cortex (PFC) of anaesthetised rats in response to a short, experimenter-provoked mechanical movement of the animal head. Movement caused significant, nerve impulse-independent elevations of glutamate levels (maximum increase, 300+/-30% of baseline). This study reveals a possible artifact in the measurement of extracellular glutamate concentrations by microdialysis and suggests that, in awake animals, treatments associated with stimulation of motor activity can cause non-specific efflux of glutamate in the PFC.

Keywords
  • Anesthesia
  • Animals
  • Arousal/physiology
  • Artifacts
  • Extracellular Space/metabolism
  • Glutamic Acid/metabolism
  • Male
  • Microdialysis/standards
  • Motor Activity/physiology
  • Movement/physiology
  • Prefrontal Cortex/metabolism
  • Rats
  • Rats, Sprague-Dawley
Affiliation Not a UNIGE publication
Citation (ISO format)
CARBONI, Sonia, ROSSETTI, Z L. Increased extracellular glutamate in rat prefrontal cortex: movement artifact contribution. In: Brain research, 2001, vol. 890, n° 1, p. 189–191.
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0006-8993
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