UNIGE document Scientific Article
previous document  unige:89767  next document
add to browser collection

Functional and structural underpinnings of neuronal assembly formation in learning

Caroni, Pico
Published in Nature Neuroscience. 2016, vol. 19, no. 12, p. 1553-1562
Abstract Learning and memory are associated with the formation and modification of neuronal assemblies: populations of neurons that encode what has been learned and mediate memory retrieval upon recall. Functional studies of neuronal assemblies have progressed dramatically thanks to recent technological advances. Here we discuss how a focus on assembly formation and consolidation has provided a powerful conceptual framework to relate mechanistic studies of synaptic and circuit plasticity to behaviorally relevant aspects of learning and memory. Neurons are likely recruited to particular learning-related assemblies as a function of their relative excitabilities and synaptic activation, followed by selective strengthening of pre-existing synapses, formation of new connections and elimination of outcompeted synapses to ensure memory formation. Mechanistically, these processes involve linking transcription to circuit modification. They include the expression of immediate early genes and specific molecular and cellular events, supported by network-wide activities that are shaped and modulated by local inhibitory microcircuits.
PMID: 27749830
Full text
Article (Published version) (778 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Research group Les circuits neuronaux dans le néocortex des mammifères (855)
(ISO format)
HOLTMAAT, Anthony, CARONI, Pico. Functional and structural underpinnings of neuronal assembly formation in learning. In: Nature Neuroscience, 2016, vol. 19, n° 12, p. 1553-1562. https://archive-ouverte.unige.ch/unige:89767

113 hits



Deposited on : 2016-12-02

Export document
Format :
Citation style :