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Scientific article
English

Trafficking/sorting and granule biogenesis in the beta-cell

Contributors

Molinete, M.; Irminger, Jean-Claude; Tooze, S. A.; Halban, Philippe A.

Published in

Seminars in cell & developmental biology, vol. 11, no. 4, p. 243-251

Publication date

2000

Abstract

Proinsulin is packaged into nascent (immature, clathrin-coated) secretory granules in the trans-Golgi network (TGN) of the beta -cell along with other granular constituents including the proinsulin conversion enzymes. It is assumed that such packaging is dependent on an active sorting process, separating granular proteins from other secretory or membrane proteins, but the mechanism remains elusive. As granules mature, the clathrin coat is lost, the intragranular milieu is progressively acidified, and proinsulin is converted to insulin and C-peptide. Loss of clathrin is believed to arise by budding of clathrin-coated vesicles from maturing granules, carrying with them any inappropriate or unnecessary products and providing an additional means for refinement of granular content.

Keywords

  • Animals
  • Biological Transport, Active
  • Clathrin/metabolism
  • Golgi Apparatus/metabolism
  • Humans
  • Insulin/biosynthesis
  • Islets of Langerhans/ metabolism/ultrastructure
  • Membrane Lipids/metabolism
  • Proinsulin/metabolism
  • Secretory Vesicles/ metabolism

UNIGE affiliation entities

Citation (ISO format)

MOLINETE, M. et al. Trafficking/sorting and granule biogenesis in the beta-cell. In: Seminars in cell & developmental biology, 2000, vol. 11, n° 4, p. 243–251. doi: 10.1006/scdb.2000.0173

Main files (1)

Article

Identifiers

Journal ISSN

1084-9521
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Technical informations

Creation

12/07/2010 11:59:09

First validation

12/07/2010 11:59:09

Update

14/03/2023 15:52:05

Status update

14/03/2023 15:52:05

Last indexation

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