UNIGE document Scientific Article
previous document  unige:8909  next document
add to browser collection

Trafficking/sorting and granule biogenesis in the beta-cell

Molinete, M.
Tooze, S. A.
Published in Seminars in cell & developmental biology. 2000, vol. 11, no. 4, p. 243-251
Abstract Proinsulin is packaged into nascent (immature, clathrin-coated) secretory granules in the trans-Golgi network (TGN) of the beta -cell along with other granular constituents including the proinsulin conversion enzymes. It is assumed that such packaging is dependent on an active sorting process, separating granular proteins from other secretory or membrane proteins, but the mechanism remains elusive. As granules mature, the clathrin coat is lost, the intragranular milieu is progressively acidified, and proinsulin is converted to insulin and C-peptide. Loss of clathrin is believed to arise by budding of clathrin-coated vesicles from maturing granules, carrying with them any inappropriate or unnecessary products and providing an additional means for refinement of granular content.
Keywords AnimalsBiological Transport, ActiveClathrin/metabolismGolgi Apparatus/metabolismHumansInsulin/biosynthesisIslets of Langerhans/ metabolism/ultrastructureMembrane Lipids/metabolismProinsulin/metabolismSecretory Vesicles/ metabolism
PMID: 10966858
Full text
Article - document accessible for UNIGE members only Limited access to UNIGE
(ISO format)
MOLINETE, M. et al. Trafficking/sorting and granule biogenesis in the beta-cell. In: Seminars in cell & developmental biology, 2000, vol. 11, n° 4, p. 243-251. doi: 10.1006/scdb.2000.0173 https://archive-ouverte.unige.ch/unige:8909

442 hits

0 download


Deposited on : 2010-07-12

Export document
Format :
Citation style :