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Title

Trafficking/sorting and granule biogenesis in the beta-cell

Authors
Molinete, M.
Tooze, S. A.
Published in Seminars in Cell and Developmental Biology. 2000, vol. 11, no. 4, p. 243-251
Abstract Proinsulin is packaged into nascent (immature, clathrin-coated) secretory granules in the trans-Golgi network (TGN) of the beta -cell along with other granular constituents including the proinsulin conversion enzymes. It is assumed that such packaging is dependent on an active sorting process, separating granular proteins from other secretory or membrane proteins, but the mechanism remains elusive. As granules mature, the clathrin coat is lost, the intragranular milieu is progressively acidified, and proinsulin is converted to insulin and C-peptide. Loss of clathrin is believed to arise by budding of clathrin-coated vesicles from maturing granules, carrying with them any inappropriate or unnecessary products and providing an additional means for refinement of granular content.
Keywords AnimalsBiological Transport, ActiveClathrin/metabolismGolgi Apparatus/metabolismHumansInsulin/biosynthesisIslets of Langerhans/ metabolism/ultrastructureMembrane Lipids/metabolismProinsulin/metabolismSecretory Vesicles/ metabolism
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PMID: 10966858
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MOLINETE, M. et al. Trafficking/sorting and granule biogenesis in the beta-cell. In: Seminars in Cell and Developmental Biology, 2000, vol. 11, n° 4, p. 243-251. https://archive-ouverte.unige.ch/unige:8909

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Deposited on : 2010-07-12

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