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25-Hydroxyvitamin D and parathyroid hormone are not associated with carotid intima-media thickness or plaque in the multi-ethnic study of atherosclerosis

Publié dansArteriosclerosis, thrombosis, and vascular biology, vol. 33, no. 11, p. 2639-2645
Date de publication2013
Résumé

OBJECTIVE: Observational evidence supports independent associations of 25-hydroxyvitamin D (25-OHD) and parathyroid hormone (PTH) with cardiovascular risk. A plausible hypothesis for these associations is accelerated development of atherosclerosis. APPROACH AND RESULTS: We evaluated cross-sectional and longitudinal associations of 25-OHD and PTH with carotid intima-media thickness (IMT) and carotid plaques among 3251 participants free of cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis. 25-OHD and PTH were measured at baseline by mass spectrometry and immunoassay, respectively. All subjects underwent a carotid ultrasound examination at baseline and 9.4 years later (median, range 8-11.1 years). Multivariable linear and logistic regressions were used to test associations of 25-OHD and PTH with the extent and progression of IMT and the prevalence and incidence of carotid plaque. Mean (SD) 25-OHD and PTH were 25.8 ng/mL (10.6) and 44.2 pg/mL (20.2), respectively. No independent associations were found between 25-OHD or PTH and IMT at baseline (increment of 1.9 μm [95% confidence interval, -5.1 to 8.9] per 10 ng/mL lower 25-OHD; increment of 0.8 μm [95% confidence interval, -3.2 to 4.8] per 10 pg/mL higher PTH) or progression of IMT (increment of 2.6 μm [95% confidence interval, -2.5 to 7.8] per 10 ng/mL lower 25-OHD, increment of 1.6 μm [95% confidence interval, -1.9 to 5.2] per 10 pg/mL higher PTH). No associations were found with the baseline prevalence of carotid plaque or the incidence of new plaques during the study period. We did not observe any interaction by race or ethnicity (White, Chinese, Black, and Hispanic). CONCLUSIONS: The consistent lack of association of vitamin D and PTH with carotid IMT and plaque suggests that these hormones may influence cardiovascular risk through pathways not reflected by carotid atherosclerosis.

Mots-clés
  • Aged
  • Carotid Artery Diseases/ethnology/metabolism/ultrasonography
  • Carotid Intima-Media Thickness
  • Continental Population Groups/statistics & numerical data
  • Cross-Sectional Studies
  • Female
  • Humans
  • Incidence
  • Logistic Models
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Parathyroid Hormone/blood
  • Plaque, Atherosclerotic/ethnology/metabolism/ultrasonography
  • Prevalence
  • Risk Factors
  • Vitamin D/analogs & derivatives/blood
Citation (format ISO)
BLONDON, Marc et al. 25-Hydroxyvitamin D and parathyroid hormone are not associated with carotid intima-media thickness or plaque in the multi-ethnic study of atherosclerosis. In: Arteriosclerosis, thrombosis, and vascular biology, 2013, vol. 33, n° 11, p. 2639–2645. doi: 10.1161/ATVBAHA.113.301781
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Article (Published version)
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Identifiants
ISSN du journal1079-5642
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Création30/10/2016 13:14:00
Première validation30/10/2016 13:14:00
Heure de mise à jour15/03/2023 00:57:10
Changement de statut15/03/2023 00:57:09
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