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Title

25-hydroxyvitamin D and parathyroid hormone levels do not predict changes in carotid arterial stiffness: the Multi-Ethnic Study of Atherosclerosis

Authors
Gepner, Adam D
Colangelo, Laura A
Korcarz, Claudia E
de Boer, Ian H
Kestenbaum, Bryan
Siscovick, David S
Kaufman, Joel D
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Published in Arteriosclerosis, Thrombosis, and Vascular Biology. 2014, vol. 34, no. 5, p. 1102-1109
Abstract OBJECTIVE: To evaluate the impact of vitamin D and parathyroid hormone (PTH) on longitudinal changes in arterial stiffness. APPROACH AND RESULTS: Distensibility coefficient and Young's elastic modulus of the right common carotid artery were evaluated at baseline and after a mean (SD) of 9.4 (0.5) years in 2580 Multi-Ethnic Study of Atherosclerosis (MESA) participants. Cross-sectional and longitudinal associations were evaluated using multivariable linear regression and analysis of covariance. At baseline, participants were 60.1 (9.4) years old (54% female; 26% black, 20% Hispanic, 14% Chinese). Mean annualized 25(OH)D was <20 ng/dL in 816 participants, and PTH was >65 pg/dL in 285 participants. In cross-sectional analyses, low 25(OH)D (<20 ng/mL) was not associated with stiffer arteries after adjustment for cardiovascular disease risk factors (P>0.4). PTH >65 pg/mL was associated with stiffer arteries after adjustment for cardiovascular disease risk factors, other than systolic blood pressure (distensibility coefficient: β=-2.4×10(-4) mm Hg(-1), P=0.003; Young's elastic modulus: β=166 mm Hg, P=0.01); however, after adjustment for systolic blood pressure, these associations no longer were statistically significant. Longitudinal arterial stiffening was associated with older age (P<0.0001), higher systolic blood pressure (P<0.008), and use of antihypertensive medications (P<0.006), but not with 25(OH)D or PTH (both P>0.1). CONCLUSIONS: Carotid arterial stiffness is not associated with low 25(OH)D concentrations. Cross-sectional associations between arterial stiffness and high PTH were attenuated by systolic blood pressure. After nearly a decade of follow-up, neither baseline PTH nor 25(OH)D concentrations were associated with progression of carotid arterial stiffness.
Keywords African AmericansAge FactorsAgedAntihypertensive Agents/therapeutic useAsian AmericansBiomarkers/bloodBlood Pressure/drug effectsCarotid Artery Diseases/blood/diagnosis/ethnology/physiopathologyCarotid Artery, Common/physiopathology/ultrasonographyCross-Sectional StudiesDisease ProgressionElastic ModulusEuropean Continental Ancestry GroupFemaleHispanic AmericansHumansHypertension/drug therapy/ethnology/physiopathologyLinear ModelsLongitudinal StudiesMaleMiddle AgedMultivariate AnalysisParathyroid Hormone/bloodPredictive Value of TestsPrevalencePrognosisRisk FactorsSystoleTime FactorsUnited States/epidemiologyVascular StiffnessVitamin D/analogs & derivatives/bloodVitamin D Deficiency/blood/diagnosis/ethnology
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PMID: 24700125
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Structures
Research group La maladie thromboembolique veineuse (808)
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GEPNER, Adam D et al. 25-hydroxyvitamin D and parathyroid hormone levels do not predict changes in carotid arterial stiffness: the Multi-Ethnic Study of Atherosclerosis. In: Arteriosclerosis, Thrombosis, and Vascular Biology, 2014, vol. 34, n° 5, p. 1102-1109. https://archive-ouverte.unige.ch/unige:89075

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Deposited on : 2016-11-18

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