Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death
ContributorsMarzban, Lucy; Rhodes, C. J.; Steiner, D. F.; Haataja, Leena; Halban, Philippe A.; Verchere, C. B.
Published inDiabetes, vol. 55, no. 8, p. 2192-2201
Publication date2006
Abstract
Keywords
- Adenoviridae/genetics
- Amyloid/ biosynthesis/genetics/metabolism
- Animals
- Apoptosis/ physiology
- Cell Line
- Gene Expression
- Green Fluorescent Proteins/genetics
- Humans
- In Situ Nick-End Labeling
- Islets of Langerhans/ enzymology
- Mice
- Mice, Inbred C57BL
- Mice, Inbred CBA
- Mice, Knockout
- Mice, Transgenic
- Peptide Fragments/metabolism
- Pituitary Gland, Anterior
- Proprotein Convertase 2/deficiency/genetics/ metabolism
- Rats
- Recombinant Fusion Proteins
- Transfection
Affiliation
Citation (ISO format)
MARZBAN, Lucy et al. Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death. In: Diabetes, 2006, vol. 55, n° 8, p. 2192–2201. doi: 10.2337/db05-1566
Updates (1)
Article

Identifiers
- PID : unige:8885
- DOI : 10.2337/db05-1566
- PMID : 16873681
ISSN of the journal0012-1797