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Scientific article
English

Enhanced hippocampal long-term potentiation and learning by increased neuronal expression of tissue-type plasminogen activator in transgenic mice

Published inEMBO journal, vol. 18, no. 11, p. 3007-3012
Publication date1999
Abstract

Adult cortical neurons can produce tissue-type plasminogen activator (tPA), an extracellular protease that plays a critical role in fibrinolysis and tissue remodelling processes. There is growing evidence that extracellular proteolysis may be involved in synaptic plasticity, axonal remodelling and neurotoxicity in the adult central nervous system. Here we show that transgenic mice overexpressing tPA in post-natal neurons have increased and prolonged hippocampal long-term potentiation (LTP), and improved performance in spatial orientation learning tasks. Extracellular proteolysis catalysed by tPA may facilitate synaptic micro-remodelling, and thereby play a role in activity-dependent neuronal plasticity and learning.

Keywords
  • Animals
  • Electrophysiology
  • Gene Expression
  • Hippocampus/anatomy & histology/cytology/ physiology
  • Learning
  • Long-Term Potentiation
  • Memory
  • Mice
  • Mice, Transgenic
  • Neurons/ metabolism/physiology
  • Space Perception
  • Swimming
  • Synapses/physiology
  • Tissue Plasminogen Activator/genetics/ metabolism
  • Transgenes/genetics
Citation (ISO format)
MADANI, Rime et al. Enhanced hippocampal long-term potentiation and learning by increased neuronal expression of tissue-type plasminogen activator in transgenic mice. In: EMBO journal, 1999, vol. 18, n° 11, p. 3007–3012. doi: 10.1093/emboj/18.11.3007
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ISSN of the journal0261-4189
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