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Title

Enhanced hippocampal long-term potentiation and learning by increased neuronal expression of tissue-type plasminogen activator in transgenic mice

Authors
Hulo, S.
Madani, H.
Steimer, T.
Published in EMBO Journal. 1999, vol. 18, no. 11, p. 3007-3012
Abstract Adult cortical neurons can produce tissue-type plasminogen activator (tPA), an extracellular protease that plays a critical role in fibrinolysis and tissue remodelling processes. There is growing evidence that extracellular proteolysis may be involved in synaptic plasticity, axonal remodelling and neurotoxicity in the adult central nervous system. Here we show that transgenic mice overexpressing tPA in post-natal neurons have increased and prolonged hippocampal long-term potentiation (LTP), and improved performance in spatial orientation learning tasks. Extracellular proteolysis catalysed by tPA may facilitate synaptic micro-remodelling, and thereby play a role in activity-dependent neuronal plasticity and learning.
Keywords AnimalsElectrophysiologyGene ExpressionHippocampus/anatomy & histology/cytology/ physiologyLearningLong-Term PotentiationMemoryMiceMice, TransgenicNeurons/ metabolism/physiologySpace PerceptionSwimmingSynapses/physiologyTissue Plasminogen Activator/genetics/ metabolismTransgenes/genetics
Identifiers
PMID: 10357813
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MADANI, Rime et al. Enhanced hippocampal long-term potentiation and learning by increased neuronal expression of tissue-type plasminogen activator in transgenic mice. In: EMBO Journal, 1999, vol. 18, n° 11, p. 3007-3012. https://archive-ouverte.unige.ch/unige:8874

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Deposited on : 2010-07-12

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