Enhanced hippocampal long-term potentiation and learning by increased neuronal expression of tissue-type plasminogen activator in transgenic mice

Madani, Rime; Hulo, S.; Toni, Nicolas; Madani, H.; Steimer, Thierry; Muller, Dominique; Vassalli, Jean-Dominique

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Title		Enhanced hippocampal long-term potentiation and learning by increased neuronal expression of tissue-type plasminogen activator in transgenic mice
Authors		Madani, Rime Hulo, S. Toni, Nicolas Madani, H. Steimer, Thierry Muller, Dominique Vassalli, Jean-Dominique
Published in		EMBO Journal. 1999, vol. 18, no. 11, p. 3007-3012
Abstract		Adult cortical neurons can produce tissue-type plasminogen activator (tPA), an extracellular protease that plays a critical role in fibrinolysis and tissue remodelling processes. There is growing evidence that extracellular proteolysis may be involved in synaptic plasticity, axonal remodelling and neurotoxicity in the adult central nervous system. Here we show that transgenic mice overexpressing tPA in post-natal neurons have increased and prolonged hippocampal long-term potentiation (LTP), and improved performance in spatial orientation learning tasks. Extracellular proteolysis catalysed by tPA may facilitate synaptic micro-remodelling, and thereby play a role in activity-dependent neuronal plasticity and learning.
Keywords		Animals — Electrophysiology — Gene Expression — Hippocampus/anatomy & histology/cytology/ physiology — Learning — Long-Term Potentiation — Memory — Mice — Mice, Transgenic — Neurons/ metabolism/physiology — Space Perception — Swimming — Synapses/physiology — Tissue Plasminogen Activator/genetics/ metabolism — Transgenes/genetics
Identifiers		DOI: 10.1093/emboj/18.11.3007 PMID: 10357813
Full text		Article - Limited access to UNIGE Other version: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1171382/pdf/003007.pdf
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine interne des spécialités Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales
Citation (ISO format)		MADANI, Rime et al. Enhanced hippocampal long-term potentiation and learning by increased neuronal expression of tissue-type plasminogen activator in transgenic mice. In: EMBO Journal, 1999, vol. 18, n° 11, p. 3007-3012. https://archive-ouverte.unige.ch/unige:8874