UNIGE document Scientific Article
previous document  unige:8744  next document
add to browser collection
Title

Polymorphisms in the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with variation in vertebral bone mass, vertebral bone size, and stature in whites

Authors
Deutsch, Samuel
Published in American Journal of Human Genetics. 2004, vol. 74, no. 5, p. 866-875
Abstract Stature, bone size, and bone mass are interrelated traits with high heritability, but the major genes that govern these phenotypes remain unknown. Independent genomewide quantitative-trait locus studies have suggested a locus for bone-mineral density and stature at chromosome 11q12-13, a region harboring the low-density lipoprotein receptor-related protein 5 (LRP5) gene. Mutations in the LRP5 gene were recently implicated in osteoporosis-pseudoglioma and "high-bone-mass" syndromes. To test whether polymorphisms in the LRP5 gene contribute to bone-mass determination in the general population, we studied a cross-sectional cohort of 889 healthy whites of both sexes. Significant associations were found for a missense substitution in exon 9 (c.2047G-->A) with lumbar spine (LS)-bone-mineral content (BMC) (P=.0032), with bone area (P=.0014), and with stature (P=.0062). The associations were observed mainly in adult men, in whom LRP5 polymorphisms accounted for <or=15% of the traits' variances. Results of haplotype analysis of five single-nucleotide polymorphisms in the LRP5 region suggest that additional genetic variation within the locus might also contribute to bone-mass and size determination. To confirm our results, we investigated whether LRP5 haplotypes were associated with 1-year gain in vertebral bone mass and size in 386 prepubertal children. Significant associations were observed for changes in BMC (P=.0348) and bone area (P=.0286) in males but not females, independently supporting our observations of a mostly male-specific effect, as seen in the adults. Together, these results suggest that LRP5 variants significantly contribute to LS-bone-mass and size determination in men by influencing vertebral bone growth during childhood.
Keywords AdolescentAdultAmino Acid SubstitutionBone Density/ geneticsBone and Bones/ cytologyChildChromosomes, Human, Pair 11/geneticsCohort StudiesCross-Sectional StudiesEuropean Continental Ancestry Group/ geneticsFemaleGene FrequencyGenetic VariationHumansLDL-Receptor Related ProteinsMaleMiddle AgedMutation, Missense/ geneticsPolymorphism, Single Nucleotide/ geneticsReceptors, LDL/ genetics
Identifiers
PMID: 15077203
Full text
Structures
Citation
(ISO format)
FERRARI, Serge Livio et al. Polymorphisms in the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with variation in vertebral bone mass, vertebral bone size, and stature in whites. In: American Journal of Human Genetics, 2004, vol. 74, n° 5, p. 866-875. https://archive-ouverte.unige.ch/unige:8744

143 hits

0 download

Update

Deposited on : 2010-07-12

Export document
Format :
Citation style :