In a few clinical cases, controlling arterial hypertension is really very difficult even when using the appropriate treatment(s) at the optimal dosage. In such cases, it is crafty to research any possible drug interferences with the antihypertensive treatment. Two clinical cases will illustrate that arterial hypertension can be either induced or very difficult to control due to opposite physiopathological mechanisms of drugs or to pharmacokinetic interactions. A review of the main interacting drug regimens will complete this paper, attesting that drugs as various as NSAID, corticosteroids, erythropoietin, cyclosporine, antidepressants, beta blockers, carbamazepine, sympathomimetics, antihistamines, tramadol and (...) can induce arterial hypertension.