UNIGE document Scientific Article
previous document  unige:86312  next document
add to browser collection
Title

The Emergence of a Circuit Model for Addiction

Author
Published in Annual Review of Neuroscience. 2016, vol. 39, p. 257-276
Abstract Addiction is a disease of altered behavior. Addicts use drugs compulsively and will continue to do so despite negative consequences. Even after prolonged periods of abstinence, addicts are at risk of relapse, particularly when cues evoke memories that are associated with drug use. Rodent models mimic many of the core components of addiction, from the initial drug reinforcement to cue-associated relapse and continued drug intake despite negative consequences. Rodent models have also enabled unprecedented mechanistic insight into addiction, revealing plasticity of glutamatergic synaptic transmission evoked by the strong activation of mesolimbic dopamine-a defining feature of all addictive drugs-as a neural substrate for these drug-adaptive behaviors. Cell type-specific optogenetic manipulations have allowed both identification of the relevant circuits and design of protocols to reverse drug-evoked plasticity and to establish links of causality with drug-adaptive behaviors. The emergence of a circuit model for addiction will open the door for novel therapies, such as deep brain stimulation.
Identifiers
PMID: 27145911
Full text
Article (Published version) (994 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Mécanismes cellulaires de la dépendance et de l'addiction (520)
Citation
(ISO format)
LUSCHER, Christian. The Emergence of a Circuit Model for Addiction. In: Annual Review of Neuroscience, 2016, vol. 39, p. 257-276. https://archive-ouverte.unige.ch/unige:86312

134 hits

0 download

Update

Deposited on : 2016-08-24

Export document
Format :
Citation style :