UNIGE document Scientific Article
previous document  unige:85272  next document
add to browser collection

Pseudo-thermosetting chitosan hydrogels for biomedical application

Berger, J.
Reist, M.
Chenite, A.
Mayer, J.
Published in International journal of pharmaceutics. 2005, vol. 288, no. 2, p. 197-206
Abstract To prepare transparent chitosan/β-glycerophosphate (βGP) pseudo-thermosetting hydrogels, the deacetylation degree (DD) of chitosan has been modified by reacetylation with acetic anhydride. Two methods (I and II) of reacetylation have been compared and have shown that the use of previously filtered chitosan, dilution of acetic anhydride and reduction of temperature in method II improves efficiency and reproducibility. Chitosans with DD ranging from 35.0 to 83.2% have been prepared according to method II under homogeneous and non-homogeneous reacetylation conditions and the turbidity of chitosan/βGP hydrogels containing homogeneously or non-homogeneously reacetylated chitosan has been investigated. Turbidity is shown to be modulated by the DD of chitosan and by the homogeneity of the medium during reacetylation, which influences the distribution mode of the chitosan monomers. The preparation of transparent chitosan/βGP hydrogels requires a homogeneously reacetylated chitosan with a DD between 35 and 50%.
Keywords ChitosanHydrogelTurbidityDrug delivery systemReacetylation
Full text
(ISO format)
BERGER, J. et al. Pseudo-thermosetting chitosan hydrogels for biomedical application. In: International journal of pharmaceutics, 2005, vol. 288, n° 2, p. 197-206. doi: 10.1016/j.ijpharm.2004.07.037 https://archive-ouverte.unige.ch/unige:85272

380 hits

1 download


Deposited on : 2016-07-14

Export document
Format :
Citation style :