en
Scientific article
English

Pseudo-thermosetting chitosan hydrogels for biomedical application

Published inInternational journal of pharmaceutics, vol. 288, no. 2, p. 197-206
Publication date2005
Abstract

To prepare transparent chitosan/β-glycerophosphate (βGP) pseudo-thermosetting hydrogels, the deacetylation degree (DD) of chitosan has been modified by reacetylation with acetic anhydride. Two methods (I and II) of reacetylation have been compared and have shown that the use of previously filtered chitosan, dilution of acetic anhydride and reduction of temperature in method II improves efficiency and reproducibility. Chitosans with DD ranging from 35.0 to 83.2% have been prepared according to method II under homogeneous and non-homogeneous reacetylation conditions and the turbidity of chitosan/βGP hydrogels containing homogeneously or non-homogeneously reacetylated chitosan has been investigated. Turbidity is shown to be modulated by the DD of chitosan and by the homogeneity of the medium during reacetylation, which influences the distribution mode of the chitosan monomers. The preparation of transparent chitosan/βGP hydrogels requires a homogeneously reacetylated chitosan with a DD between 35 and 50%.

Keywords
  • Chitosan
  • Hydrogel
  • Turbidity
  • Drug delivery system
  • Reacetylation
Citation (ISO format)
BERGER, J. et al. Pseudo-thermosetting chitosan hydrogels for biomedical application. In: International journal of pharmaceutics, 2005, vol. 288, n° 2, p. 197–206. doi: 10.1016/j.ijpharm.2004.07.037
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ISSN of the journal0378-5173
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