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New surface-active polymers for ophthalmic formulations: evaluation of ocular tolerance

Baydoun, Luma
Furrer, Pascal
Müller-Goymann, Christel C.
Published in European Journal of Pharmaceutics and Biopharmaceutics. 2004, vol. 58, no. 1, p. 169-175
Abstract Two n-octenylsuccinate starch (AS) types of unknown molecular weights were assessed for ocular tolerance. Irritation potential of different solutions (containing 2 and 15% (w/w) AS) and AS stabilized emulsions (containing 15% (w/w) AS) was evaluated in vivo in rabbit eyes, using a confocal laser scanning microscope, and in vitro on treated excised pig corneas by light microscopy of histological cross sections. Both AS types were previously characterized by viscosity, osmolality and surface tension measurements. All tested solutions and emulsions showed good eye tolerance regardless of concentration and emulsifying properties suggesting AS to be a good alternative to commonly used solubilizing or emulsifying agents in ophthalmic formulations.
Keywords N-Octenylsuccinate starchOcular toleranceConfocal laser scanning microscopyCornea histologyOphthalmic formulations
PMID: 15207551
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BAYDOUN, Luma et al. New surface-active polymers for ophthalmic formulations: evaluation of ocular tolerance. In: European Journal of Pharmaceutics and Biopharmaceutics, 2004, vol. 58, n° 1, p. 169-175. doi: 10.1016/j.ejpb.2004.03.005 https://archive-ouverte.unige.ch/unige:84831

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Deposited on : 2016-06-29

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