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Title

Very Long Term Stability of Mixed Chimerism after Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Hematologic Malignancies

Authors
Levrat, Emmanuel
Mohty, Bilal
Passweg, Jakob R.
Published in Bone Marrow Research. 2015
Abstract The objective of this study is to analyze the evolution of chimerism of all patients transplanted for hematologic malignancies in our unit during a 20-year period, alive without relapse at 1 year after allogeneic hematopoietic stem cell transplantation (HSCT). Chimerismwas tested using short tandem repeat polymorphisms after separation intomononuclear cells and granulocytes by Ficoll density gradient centrifugation. Of 155 patients studied, 89 had full chimerism (FC), 36 mononuclear cells mixed chimerism (MNCMC), and 30 granulocytic MC with or without mononuclear cells MC (Gran-MC). Survival was significantly better in MNC-MC than in Gran-MC patients, with FC patients being intermediate. There was more disease relapse in the Gran-MC group but not in the MNC-MC group as compared to FC. MC was stable up to 21 years in the MNC-MC group and up to 19 years in the Gran-MC group. Of MC patients alive at 10 years, MC persisted in 83% in the MNC-MC and 57% in the Gran-MC groups. In conclusion, mixed chimerism may remain stable over a very long time period. In survivors without relapse at 1 year after HSCT, determining lineage specific chimerism may be useful as outcome differs, MNC-MC being associated with better outcome than Gran-MC.
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Article (Published version) (718 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://www.hindawi.com/journals/bmr/2015/176526/
Structures
Research groups Plateforme d'oncologie et d'hématologie pédiatrique (907)
Groupe Roosnek Eddy (hémato-oncologie) (19)
Transplantation immunologie et osteoimmunologie (561)
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LEVRAT, Emmanuel et al. Very Long Term Stability of Mixed Chimerism after Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Hematologic Malignancies. In: Bone Marrow Research, 2015. https://archive-ouverte.unige.ch/unige:83631

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Deposited on : 2016-05-09

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