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Title

Modelling the electrophysiological endothelial cell response to bradykinin

Authors
Schuster, Alexander
Meister, Jean-Jacques
Published in European Biophysics Journal. 2003, vol. 32, no. 4, p. 370-380
Abstract The goal of the present study is to construct a biophysical model of the coronary artery endothelial cell response to bradykinin. This model takes into account intracellular Ca2+ dynamics, membrane potential, a non-selective cation channel, and two Ca(2+)-dependent K+ channels, as well as intra- and extracellular Ca2+ sources. The model reproduces the experimental data available, and predicts certain quantities which would be hard to obtain experimentally, like the individual K+ channel currents when the membrane potential is allowed to freely evolve, the implication of epoxyeicosatrienoic acids (EETs), and the total K+ released during stimulation. The main results are: (1) the large-conductance K+ channel participates only very little in the overall response; (2) EETs are required in order to explain the experimental current-potential relationships, but are not an essential component of the bradykinin response; and (3) the total K+ released during stimulation gives rise to a concentration in the intercellular space which is of millimolar order. This concentration change is compatible with the hypothesis that K+ contributes to the endothelium-derived hyperpolarizing factor phenomenon.
Keywords Calcium ion dynamicsEndotheliumderived hyperpolarizing factorEpoxyeicosatrienoic acidsMembrane potentialPotassium ion channels
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PMID: 12851795
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SCHUSTER, Alexander, BENY, Jean-Louis, MEISTER, Jean-Jacques. Modelling the electrophysiological endothelial cell response to bradykinin. In: European Biophysics Journal, 2003, vol. 32, n° 4, p. 370-380. https://archive-ouverte.unige.ch/unige:83287

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Deposited on : 2016-04-21

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