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Enantioselective nucleophilic opening of meso epoxides by organolithium reagents |
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Authors | ||
Published in | Synlett. 1998, no. 10, p. 1165-1167 | |
Abstract | Aryl lithium reagents, complexed with (-)-sparteine, react enantioselectively with cyclic meso epoxides, to afford chiral aryl cyclanols. The enantiomeric excess, though moderate (27-87%), is the best in the literature for such a reaction. Activation by BF3 · OEt2 is needed, and is compatible with a diamine such as (-)-sparteine. | |
Keywords | epoxides — organolithium reagents — BF3 Et2O activation — (-)-sparteine | |
Identifiers | DOI: 10.1055/s-1998-5741 | |
Full text | ||
Citation (ISO format) | ALEXAKIS, Alexandre, VRANCKEN, Emmanuel, MANGENEY, Pierre. Enantioselective nucleophilic opening of meso epoxides by organolithium reagents. In: Synlett, 1998, n° 10, p. 1165-1167. doi: 10.1055/s-1998-5741 https://archive-ouverte.unige.ch/unige:8156 |