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Scientific Article
unige:8156 
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Enantioselective nucleophilic opening of meso epoxides by organolithium reagents |
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| Authors | ||
| Published in | Synlett. 1998, no. 10, p. 1165-1167 | |
| Abstract | Aryl lithium reagents, complexed with (-)-sparteine, react enantioselectively with cyclic meso epoxides, to afford chiral aryl cyclanols. The enantiomeric excess, though moderate (27-87%), is the best in the literature for such a reaction. Activation by BF3 · OEt2 is needed, and is compatible with a diamine such as (-)-sparteine. | |
| Keywords | epoxides — organolithium reagents — BF3 Et2O activation — (-)-sparteine | |
| Identifiers | DOI: 10.1055/s-1998-5741 | |
| Full text | ||
| Citation (ISO format) | ALEXAKIS, Alexandre, VRANCKEN, Emmanuel, MANGENEY, Pierre. Enantioselective nucleophilic opening of meso epoxides by organolithium reagents. In: Synlett, 1998, n° 10, p. 1165-1167. doi: 10.1055/s-1998-5741 https://archive-ouverte.unige.ch/unige:8156 |
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