Scientific Article
previous document  unige:8156  next document
add to browser collection
Title

Enantioselective nucleophilic opening of meso epoxides by organolithium reagents

Authors
Vrancken, Emmanuel
Mangeney, Pierre
Published in Synlett. 1998, no. 10, p. 1165-1167
Abstract Aryl lithium reagents, complexed with (-)-sparteine, react enantioselectively with cyclic meso epoxides, to afford chiral aryl cyclanols. The enantiomeric excess, though moderate (27-87%), is the best in the literature for such a reaction. Activation by BF3 · OEt2 is needed, and is compatible with a diamine such as (-)-sparteine.
Keywords epoxidesorganolithium reagentsBF3 Et2O activation(-)-sparteine
Identifiers
Full text
Article (Published version) - document accessible for UNIGE members only Limited access to UNIGE
Citation
(ISO format)
ALEXAKIS, Alexandre, VRANCKEN, Emmanuel, MANGENEY, Pierre. Enantioselective nucleophilic opening of meso epoxides by organolithium reagents. In: Synlett, 1998, n° 10, p. 1165-1167. https://archive-ouverte.unige.ch/unige:8156

206 hits

1 download

Update

Deposited on : 2010-06-21

Export document
Format :
Citation style :