UNIGE document Scientific Article
previous document  unige:8054  next document
add to browser collection
Title

Enantioselective opening of cyclic vinyl epoxides with organoaluminium reagents catalysed by copper salts

Authors
Published in Tetrahedron: Asymmetry. 2004, vol. 15, no. 10, p. 1531-1536
Abstract Herein we report conditions for the enantioselective conjugate addition of trialkylaluminium reagents to cyclic vinyl epoxides catalysed by copper salts and chiral phosphorus-based ligands. The reaction must be carried out in THF, otherwise we observed only oligomeric products. The best ees have been obtained with CuTC as the copper salt and a 2,2'-binaphthyl-based phosphorus ligand. Both opening products (SN2 and SN2' pathways) were obtained with good enantioselectivity and moderate to good regioselectivity.
Identifiers
Full text
Article (Published version) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Citation
(ISO format)
EQUEY, Olivier, ALEXAKIS, Alexandre. Enantioselective opening of cyclic vinyl epoxides with organoaluminium reagents catalysed by copper salts. In: Tetrahedron: Asymmetry, 2004, vol. 15, n° 10, p. 1531-1536. https://archive-ouverte.unige.ch/unige:8054

188 hits

26 downloads

Update

Deposited on : 2010-06-21

Export document
Format :
Citation style :