en
Scientific article
Letter
English

Diamine-catalyzed asymmetric Michael additions of aldehydes and ketones to nitrostyrene

Published inOrganic letters, vol. 4, no. 21, p. 3611-3614
Publication date2002
Abstract

The direct Michael addition of aldehydes and ketones to nitrostyrene, catalyzed by N-i-Pr-2,2'-bipyrrolidine, is described. The desired 1,4-adducts are obtained in excellent yield with enantioselectivities up to 85% ee and dr up to 95:5 of the syn product.

Citation (ISO format)
ALEXAKIS, Alexandre, ANDREY, Olivier. Diamine-catalyzed asymmetric Michael additions of aldehydes and ketones to nitrostyrene. In: Organic letters, 2002, vol. 4, n° 21, p. 3611–3614. doi: 10.1021/ol026543q
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ISSN of the journal1523-7052
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