Biphenol-based phosphoramidite ligands for the enantioselective copper-catalyzed conjugate addition of diethylzinc

Alexakis, Alexandre; Polet, Damien; Rosset, Stéphane; March, Sebastien

doi:10.1021/jo049359m

Scientific article

English

Biphenol-based phosphoramidite ligands for the enantioselective copper-catalyzed conjugate addition of diethylzinc

ContributorsAlexakis, Alexandre; Polet, Damien; Rosset, Stéphane; March, Sebastien

Published inJournal of organic chemistry, vol. 69, no. 17, p. 5660-5667

Publication date2004

Abstract

Phosphoramidite ligands, based on ortho-substituted biphenols and a chiral amine, induce high enantioselectivities (ee's up to 99%) in the copper-catalyzed conjugate addition of dialkylzinc reagents to a variety of Michael acceptors. Particularly, the best reported ee's were obtained for acyclic nitroolefins.

Affiliation

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Citation (ISO format)

ALEXAKIS, Alexandre et al. Biphenol-based phosphoramidite ligands for the enantioselective copper-catalyzed conjugate addition of diethylzinc. In: Journal of organic chemistry, 2004, vol. 69, n° 17, p. 5660–5667. doi: 10.1021/jo049359m

Article (Published version)

Identifiers

PID : unige:8031
DOI : 10.1021/jo049359m
PMID : 15307737

ISSN of the journal0022-3263

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Biphenol-based phosphoramidite ligands for the enantioselective copper-catalyzed conjugate addition of diethylzinc

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