• Home
  1. Home
  2. Copper-catalyzed asymmetric conjugate addition of Grignard reagents to trisubstituted enones. Construction of all-carbon quaternary centers
Scientific article
English

Copper-catalyzed asymmetric conjugate addition of Grignard reagents to trisubstituted enones. Construction of all-carbon quaternary centers

Contributors

Martin, David; Kehrli, Stefan; Vuagnoux-D'Augustin De, Magali; Clavier, Hervé; Mauduit, Marc; Alexakis, Alexandre

Published in

Journal of the American Chemical Society, vol. 128, no. 26, p. 8416-8417

Publication date

2006

Abstract

The copper-catalyzed asymmetric conjugate addition of Grignard reagents to trisubstituted cyclic enones affords enantioenriched all-carbon quaternary centers with up to 96% ee. The chiral ligand is a diaminocarbene, directly generated in situ. The combination of Grignard reagent and diaminocarbene is unprecedented in conjugate addition, and the additon of the phenyl group, on such enones, cannot be done by other conjugate addition methods.

UNIGE affiliation entities

Citation (ISO format)

MARTIN, David et al. Copper-catalyzed asymmetric conjugate addition of Grignard reagents to trisubstituted enones. Construction of all-carbon quaternary centers. In: Journal of the American Chemical Society, 2006, vol. 128, n° 26, p. 8416–8417. doi: 10.1021/ja0629920

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

0002-7863
601views
5downloads

Technical informations

Creation

21/06/2010 14:15:40

First validation

21/06/2010 14:15:40

Update

14/03/2023 15:47:43

Status update

14/03/2023 15:47:43

Last indexation

10/06/2025 21:35:29
All rights reserved by Archive ouverte UNIGE and the University of Geneva
OpenAIRE Indexed & Validated