BARD1 mediates TGF-β signaling in pulmonary fibrosis

Andre, Pierre-Alain; Prêle, Cecilia M; Vierkotten, Sarah; Carnesecchi, Stéphanie; Donati, Yves Richard; Chambers, Rachel C; Pache, Jean-Claude; Crestani, Bruno; Barazzone, Constance; Königshoff, Melanie; Laurent, Geoffrey J; Irminger-Finger, Irmgard

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Title		BARD1 mediates TGF-β signaling in pulmonary fibrosis
Authors		Andre, Pierre-Alain Prêle, Cecilia M Vierkotten, Sarah Carnesecchi, Stéphanie Donati, Yves Richard Chambers, Rachel C Pache, Jean-Claude Crestani, Bruno Barazzone, Constance Königshoff, Melanie Laurent, Geoffrey J Irminger-Finger, Irmgard show all authors [1 - 12]
Published in		Respiratory Research. 2015, vol. 16, p. 118
Abstract		Idiopathic pulmonary fibrosis (IPF) is a rapid progressive fibro-proliferative disorder with poor prognosis similar to lung cancer. The pathogenesis of IPF is uncertain, but loss of epithelial cells and fibroblast proliferation are thought to be central processes. Previous reports have shown that BARD1 expression is upregulated in response to hypoxia and associated with TGF-β signaling, both recognized factors driving lung fibrosis. Differentially spliced BARD1 isoforms, in particular BARD1β, are oncogenic drivers of proliferation in cancers of various origins. We therefore hypothesized that BARD1 and/or its isoforms might play a role in lung fibrosis.
Identifiers		DOI: 10.1186/s12931-015-0278-3 PMID: 26415510
Full text		Article (Author postprint) (2.1 MB) - Free access
Structures		Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté de médecine / Section de médecine clinique / Département de pédiatrie Faculté de médecine / Section de médecine clinique / Département de gynécologie et d'obstétrique
Research groups		Groupe Pache Jean-Claude (pathologie clinique) (658) Facteurs influençants le développement pulmonaire: étude translationnelle chez l'animal et l'homme (182)
Citation (ISO format)		ANDRE, Pierre-Alain et al. BARD1 mediates TGF-β signaling in pulmonary fibrosis. In: Respiratory Research, 2015, vol. 16, p. 118. https://archive-ouverte.unige.ch/unige:79907