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BARD1 mediates TGF-β signaling in pulmonary fibrosis

Prêle, Cecilia M
Vierkotten, Sarah
Chambers, Rachel C
Crestani, Bruno
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Published in Respiratory research. 2015, vol. 16, 118
Abstract Idiopathic pulmonary fibrosis (IPF) is a rapid progressive fibro-proliferative disorder with poor prognosis similar to lung cancer. The pathogenesis of IPF is uncertain, but loss of epithelial cells and fibroblast proliferation are thought to be central processes. Previous reports have shown that BARD1 expression is upregulated in response to hypoxia and associated with TGF-β signaling, both recognized factors driving lung fibrosis. Differentially spliced BARD1 isoforms, in particular BARD1β, are oncogenic drivers of proliferation in cancers of various origins. We therefore hypothesized that BARD1 and/or its isoforms might play a role in lung fibrosis.
PMID: 26415510
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Research groups Facteurs influençants le développement pulmonaire: étude translationnelle chez l'animal et l'homme (182)
Groupe Pache Jean-Claude (pathologie clinique) (658)
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ANDRE, Pierre-Alain et al. BARD1 mediates TGF-β signaling in pulmonary fibrosis. In: Respiratory research, 2015, vol. 16, p. 118. doi: 10.1186/s12931-015-0278-3 https://archive-ouverte.unige.ch/unige:79907

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Deposited on : 2016-01-22

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