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Scientific article
Open access
English

BARD1 mediates TGF-β signaling in pulmonary fibrosis

Published inRespiratory research, vol. 16, 118
Publication date2015
Abstract

Idiopathic pulmonary fibrosis (IPF) is a rapid progressive fibro-proliferative disorder with poor prognosis similar to lung cancer. The pathogenesis of IPF is uncertain, but loss of epithelial cells and fibroblast proliferation are thought to be central processes. Previous reports have shown that BARD1 expression is upregulated in response to hypoxia and associated with TGF-β signaling, both recognized factors driving lung fibrosis. Differentially spliced BARD1 isoforms, in particular BARD1β, are oncogenic drivers of proliferation in cancers of various origins. We therefore hypothesized that BARD1 and/or its isoforms might play a role in lung fibrosis.

Citation (ISO format)
ANDRE, Pierre-Alain et al. BARD1 mediates TGF-β signaling in pulmonary fibrosis. In: Respiratory research, 2015, vol. 16, p. 118. doi: 10.1186/s12931-015-0278-3
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Article (Accepted version)
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ISSN of the journal1465-9921
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Technical informations

Creation11/24/2015 10:05:00 AM
First validation11/24/2015 10:05:00 AM
Update time03/15/2023 12:05:17 AM
Status update03/15/2023 12:05:16 AM
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