UNIGE document Scientific Article
previous document  unige:79907  next document
add to browser collection
Title

BARD1 mediates TGF-β signaling in pulmonary fibrosis

Authors
Prêle, Cecilia M
Vierkotten, Sarah
Chambers, Rachel C
Crestani, Bruno
show hidden authors show all authors [1 - 12]
Published in Respiratory Research. 2015, vol. 16, p. 118
Abstract Idiopathic pulmonary fibrosis (IPF) is a rapid progressive fibro-proliferative disorder with poor prognosis similar to lung cancer. The pathogenesis of IPF is uncertain, but loss of epithelial cells and fibroblast proliferation are thought to be central processes. Previous reports have shown that BARD1 expression is upregulated in response to hypoxia and associated with TGF-β signaling, both recognized factors driving lung fibrosis. Differentially spliced BARD1 isoforms, in particular BARD1β, are oncogenic drivers of proliferation in cancers of various origins. We therefore hypothesized that BARD1 and/or its isoforms might play a role in lung fibrosis.
Identifiers
PMID: 26415510
Full text
Article (Author postprint) (2.1 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research groups Groupe Pache Jean-Claude (pathologie clinique) (658)
Facteurs influençants le développement pulmonaire: étude translationnelle chez l'animal et l'homme (182)
Citation
(ISO format)
ANDRE, Pierre-Alain et al. BARD1 mediates TGF-β signaling in pulmonary fibrosis. In: Respiratory Research, 2015, vol. 16, p. 118. https://archive-ouverte.unige.ch/unige:79907

107 hits

0 download

Update

Deposited on : 2016-01-22

Export document
Format :
Citation style :