UNIGE document Scientific Article
previous document  unige:79550  next document
add to browser collection

Baclofen-Associated Onset of Central Sleep Apnea in Alcohol Use Disorder: A Case Report

Pépin, Jean Louis
Espa, Fabrice
show hidden authors show all authors [1 - 10]
Published in Respiration. 2015, vol. 90, no. 6, p. 507-511
Abstract A 61-year-old patient with alcohol use disorder (AUD) was referred for suspicion of sleep apnea syndrome (SAS). He had incurred three road accidents attributed to sleepiness over the previous year, shortly after initiation of high-dose (100 mg b.i.d.) treatment with baclofen, a molecule increasingly used in the management of AUD. Polysomnography revealed a severe central SAS (CSAS) with an apnea-hypopnea index (AHI) of 81.6/h. Baclofen was suggested as a possible cause of the CSAS, and after its withdrawal, a second polysomnography was done, showing the disappearance of the central apneas and a shift to severe obstructive SAS (AHI 43.9/h), for which a positive airway pressure (CPAP) treatment was initiated. A third polysomnography was performed under CPAP after reintroduction of baclofen (50 mg b.i.d.) by the patient, showing reappearance of the CSAS (AHI 42.1/h). This case report illustrates the deleterious effect of baclofen on breathing physiology during sleep. Since it is typically prescribed off label at high doses to a population of patients potentially using other substances that inhibit the ventilatory drive, this possible adverse effect is a major concern. When considering the use of baclofen in patients with AUD, the potential for sleep-disordered breathing should be weighed and carefully monitored.
PMID: 26390141
Full text
Article (Published version) (546 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Research groups Groupe Gasche-Soccal Paola (958)
Groupe Desmeules Jules (pharmacologie/toxicologie) (567)
(ISO format)
PEROGAMVROS, Lampros et al. Baclofen-Associated Onset of Central Sleep Apnea in Alcohol Use Disorder: A Case Report. In: Respiration, 2015, vol. 90, n° 6, p. 507-511. https://archive-ouverte.unige.ch/unige:79550

86 hits

0 download


Deposited on : 2016-01-19

Export document
Format :
Citation style :