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Title

Chiroptical Rhythmicity, Part 3: Implications on the Activity of the Functional Cell-Surface Receptor Model

Authors
Tedesco, Maureen M.
Ghebremariam, Bereket
Published in Colloids and Surfaces. A, Physicochemical and Engineering Aspects. 2000, vol. 169, no. 1-3, p. 5-11
Abstract The effect of ligand-induced rhythmical structural changes of the artificial receptor 1 on its capacity to mediate ion transport across lipid bilayer membranes was studied. The changes of the intravesicular pH of egg yolk phosphatidylcholine-small unilamellar vesicles (EYPC-SUVs) after application of a transmembrane proton gradient were measured by double-channel fluorescence kinetics in the presence of 1 at various concentrations of the extravesicular ligand Image L-His. Comparison with negative control experiments using Image D-His indicated that increasing concentrations of Image L-His affect the activity of 1 in a presumably rhythmical manner. Compared to the extent of structural rhythmicity, the functional rhythmicity of 1 appeared, however, less significant. The need for refined assay systems to fully delineate the importance of rhythmical activity of 1 with respect to biological rhythmicity is briefly discussed.
Keywords Biological rhythmicityCircular dichroismIon transportLipid bilayerOligophenylenesReceptor models
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TEDESCO, Maureen M., GHEBREMARIAM, Bereket, MATILE, Stefan. Chiroptical Rhythmicity, Part 3: Implications on the Activity of the Functional Cell-Surface Receptor Model. In: Colloids and Surfaces. A, Physicochemical and Engineering Aspects, 2000, vol. 169, n° 1-3, p. 5-11. https://archive-ouverte.unige.ch/unige:7914

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Deposited on : 2010-06-21

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