Scientific article

Role of LBPA and Alix in Multivesicular Liposome Formation and Endosome Organization

Published inScience, vol. 303, no. 5657, p. 531-534
Publication date2004

What are the components that control the assembly of subcellular organelles in eukaryotic cells? Although membranes can clearly be distorted by cytosolic factors, very little is known about the intrinsic mechanisms that control the biogenesis, shape, and organization of organellar membranes. Here, we found that the unconventional phospholipid lysobisphosphatidic acid (LBPA) could induce the formation of multivesicular liposomes that resembled the multivesicular endosomes that exist where this lipid is found in vivo. This process depended on the same pH gradient that exists across endosome membranes in vivo and was selectively controlled by Alix. In turn, Alix regulated the organization of LBPA-containing endosomes in vivo.

Citation (ISO format)
MATSUO, Hirotami et al. Role of LBPA and Alix in Multivesicular Liposome Formation and Endosome Organization. In: Science, 2004, vol. 303, n° 5657, p. 531–534. doi: 10.1126/science.1092425
Main files (1)
ISSN of the journal0036-8075

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