en
Scientific article
Open access
English

Optimal estimation reconstruction of the optical properties of a two-layered tissue phantom from time-resolved single-distance measurements

Published inJournal of biomedical optics, vol. 20, no. 11, 115001
Publication date2015
Abstract

In this work, we have tested the optimal estimation (OE) algorithm for the reconstruction of the optical properties of a two-layered liquid tissue phantom from time-resolved single-distance measurements. The OE allows a priori information, in particular on the range of variation of fit parameters, to be included. The purpose of the present investigations was to compare the performance of OE with the Levenberg–Marquardt method for a geometry and real experimental conditions typically used to reconstruct the optical properties of biological tissues such as muscle and brain. The absorption coefficient of the layers was varied in a range of values typical for biological tissues. The reconstructions performed demonstrate the substantial improvements achievable with the OE provided a priori information is available. We note the extreme reliability, robustness, and accuracy of the retrieved absorption coefficient of the second layer obtained with the OE that was found for up to six fit parameters, with an error in the retrieved values of less than 10%. A priori information on fit parameters and fixed forward model parameters clearly improves robustness and accuracy of the inversion procedure.

Citation (ISO format)
MARTELLI, Fabrizio et al. Optimal estimation reconstruction of the optical properties of a two-layered tissue phantom from time-resolved single-distance measurements. In: Journal of biomedical optics, 2015, vol. 20, n° 11, p. 115001. doi: 10.1117/1.JBO.20.11.115001
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal1083-3668
541views
377downloads

Technical informations

Creation11/03/2015 11:00:00 AM
First validation11/03/2015 11:00:00 AM
Update time03/14/2023 11:57:32 PM
Status update03/14/2023 11:57:31 PM
Last indexation01/16/2024 7:47:34 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack