Serotonin receptor 3A controls interneuron migration into the neocortex

Murthy, Sahana; Niquille, Mathieu; Hurni, Nicolas; Limoni, Greta; Frazer, Sarah Louise; Chameau, Pascal; van Hooft, Johannes A; Vitalis, Tania; Dayer, Alexandre

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Title		Serotonin receptor 3A controls interneuron migration into the neocortex
Authors		Murthy, Sahana Niquille, Mathieu Hurni, Nicolas Limoni, Greta Frazer, Sarah Louise Chameau, Pascal van Hooft, Johannes A Vitalis, Tania Dayer, Alexandre show all authors [1 - 9]
Published in		Nature Communications. 2014, vol. 5, p. 5524
Abstract		Neuronal excitability has been shown to control the migration and cortical integration of reelin-expressing cortical interneurons (INs) arising from the caudal ganglionic eminence (CGE), supporting the possibility that neurotransmitters could regulate this process. Here we show that the ionotropic serotonin receptor 3A (5-HT(3A)R) is specifically expressed in CGE-derived migrating interneurons and upregulated while they invade the developing cortex. Functional investigations using calcium imaging, electrophysiological recordings and migration assays indicate that CGE-derived INs increase their response to 5-HT(3A)R activation during the late phase of cortical plate invasion. Using genetic loss-of-function approaches and in vivo grafts, we further demonstrate that the 5-HT(3A)R is cell autonomously required for the migration and proper positioning of reelin-expressing CGE-derived INs in the neocortex. Our findings reveal a requirement for a serotonin receptor in controlling the migration and laminar positioning of a specific subtype of cortical IN.
Identifiers		DOI: 10.1038/ncomms6524 PMID: 25409778
Full text		Article (Published version) (2.7 MB) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département de psychiatrie Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales
Research group		Groupe Dayer Alexandre (Formation du circuit cortical) (875)
Citation (ISO format)		MURTHY, Sahana et al. Serotonin receptor 3A controls interneuron migration into the neocortex. In: Nature Communications, 2014, vol. 5, p. 5524. https://archive-ouverte.unige.ch/unige:77918