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Serotonin receptor 3A controls interneuron migration into the neocortex

Murthy, Sahana
Chameau, Pascal
van Hooft, Johannes A
Vitalis, Tania
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Published in Nature Communications. 2014, vol. 5, 5524
Abstract Neuronal excitability has been shown to control the migration and cortical integration of reelin-expressing cortical interneurons (INs) arising from the caudal ganglionic eminence (CGE), supporting the possibility that neurotransmitters could regulate this process. Here we show that the ionotropic serotonin receptor 3A (5-HT(3A)R) is specifically expressed in CGE-derived migrating interneurons and upregulated while they invade the developing cortex. Functional investigations using calcium imaging, electrophysiological recordings and migration assays indicate that CGE-derived INs increase their response to 5-HT(3A)R activation during the late phase of cortical plate invasion. Using genetic loss-of-function approaches and in vivo grafts, we further demonstrate that the 5-HT(3A)R is cell autonomously required for the migration and proper positioning of reelin-expressing CGE-derived INs in the neocortex. Our findings reveal a requirement for a serotonin receptor in controlling the migration and laminar positioning of a specific subtype of cortical IN.
PMID: 25409778
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Research group Groupe Dayer Alexandre (Formation du circuit cortical) (875)
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MURTHY, Sahana et al. Serotonin receptor 3A controls interneuron migration into the neocortex. In: Nature communications, 2014, vol. 5, p. 5524. doi: 10.1038/ncomms6524 https://archive-ouverte.unige.ch/unige:77918

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Deposited on : 2015-11-30

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