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Apicomplexan Energy Metabolism: Carbon Source Promiscuity and the Quiescence Hyperbole

Waller, Ross F
MacPherson, Dougal A
MacRae, James I
Published in Trends in Parasitology. 2015, no. 1425
Abstract The nature of energy metabolism in apicomplexan parasites has been closely investigated in the recent years. Studies in Plasmodium spp. and Toxoplasma gondii in particular have revealed that these parasites are able to employ enzymes in non-traditional ways, while utilizing multiple anaplerotic routes into a canonical tricarboxylic acid (TCA) cycle to satisfy their energy requirements. Importantly, some life stages of these parasites previously considered to be metabolically quiescent are, in fact, active and able to adapt their carbon source utilization to survive. We compare energy metabolism across the life cycle of malaria parasites and consider how this varies in other apicomplexans and related organisms, while discussing how this can be exploited for therapeutic intervention in these diseases.
PMID: 26472327
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Article (Author postprint) (3.2 MB) - public document Free access
Research group Biologie d'un parasite intracellulaire obligatoire (773)
Project SystemsX.ch
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JACOT, Damien et al. Apicomplexan Energy Metabolism: Carbon Source Promiscuity and the Quiescence Hyperbole. In: Trends in Parasitology, 2015, n° 1425. https://archive-ouverte.unige.ch/unige:77863

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Deposited on : 2015-11-30

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