en
Scientific article
Open access
English

Evidence for the gut microbiota short-chain fatty acids as key pathophysiological molecules improving diabetes

Published inMediators of inflammation, vol. 2014, 162021
Publication date2014
Abstract

In type 2 diabetes, hyperglycemia, insulin resistance, increased inflammation, and oxidative stress were shown to be associated with the progressive deterioration of beta-cell function and mass. Short-chain fatty acids (SCFAs) are organic fatty acids produced in the distal gut by bacterial fermentation of macrofibrous material that might improve type 2 diabetes features. Their main beneficial activities were identified in the decrease of serum levels of glucose, insulin resistance as well as inflammation, and increase in protective Glucagon-like peptide-1 (GLP-1) secretion. In this review, we updated evidence on the effects of SCFAs potentially improving metabolic control in type 2 diabetes.

Keywords
  • Animals
  • Diabetes Mellitus, Type 2/metabolism
  • Fatty Acids, Volatile/metabolism
  • Gastrointestinal Tract/microbiology
  • Glucose/metabolism
  • Humans
  • Microbiota/physiology
Citation (ISO format)
PUDDU, Alessandra et al. Evidence for the gut microbiota short-chain fatty acids as key pathophysiological molecules improving diabetes. In: Mediators of inflammation, 2014, vol. 2014, p. 162021. doi: 10.1155/2014/162021
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Article (Published version)
Identifiers
ISSN of the journal0962-9351
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