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Title

Evidence for the gut microbiota short-chain fatty acids as key pathophysiological molecules improving diabetes

Authors
Puddu, Alessandra
Sanguineti, Roberta
Viviani, Giorgio Luciano
Published in Mediators of Inflammation. 2014, vol. 2014, p. 162021
Abstract In type 2 diabetes, hyperglycemia, insulin resistance, increased inflammation, and oxidative stress were shown to be associated with the progressive deterioration of beta-cell function and mass. Short-chain fatty acids (SCFAs) are organic fatty acids produced in the distal gut by bacterial fermentation of macrofibrous material that might improve type 2 diabetes features. Their main beneficial activities were identified in the decrease of serum levels of glucose, insulin resistance as well as inflammation, and increase in protective Glucagon-like peptide-1 (GLP-1) secretion. In this review, we updated evidence on the effects of SCFAs potentially improving metabolic control in type 2 diabetes.
Keywords AnimalsDiabetes Mellitus, Type 2/metabolismFatty Acids, Volatile/metabolismGastrointestinal Tract/microbiologyGlucose/metabolismHumansMicrobiota/physiology
Identifiers
PMID: 25214711
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Research group L'athérosclérose et ses complications cliniques (591)
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PUDDU, Alessandra et al. Evidence for the gut microbiota short-chain fatty acids as key pathophysiological molecules improving diabetes. In: Mediators of Inflammation, 2014, vol. 2014, p. 162021. https://archive-ouverte.unige.ch/unige:77531

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Deposited on : 2015-11-23

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