UNIGE document Scientific Article
previous document  unige:77509  next document
add to browser collection

Role of matrix metalloproteinase-8 in atherosclerosis

Published in Mediators of Inflammation. 2013, vol. 2013, p. 659282
Abstract Plaque rupture is the main cause of acute myocardial infarction and stroke. Atherosclerotic plaques have been described to be vulnerable and more prone to rupture when they are characterized by thin, highly inflamed, and collagen-poor fibrous caps and contain elevated levels of proteases, including metalloproteinases (MMPs). Initiation of collagen breakdown in plaques requires interstitial collagenases, a MMP subfamily consisting of MMP-1, MMP-8, and MMP-13. Previous reports demonstrated that MMP-1 and MMP-13 might be overexpressed in both human and experimental atherosclerosis. Since neutrophils have been only recently reported in atherosclerotic plaques, the role of MMP-8 (formerly known as "neutrophil collagenase") was only marginally evaluated. In this paper, we will update and comment on evidence of the most relevant regulatory pathways and activities mediated by MMP-8 in atherogenesis.
Keywords AnimalsAtherosclerosis/blood/enzymology/metabolism/pathologyHumansMatrix Metalloproteinase 8/blood/genetics/metabolism
PMID: 23365489
Full text
Article (Published version) (1.3 MB) - public document Free access
Research group L'athérosclérose et ses complications cliniques (591)
(ISO format)
LENGLET, Sébastien, MACH, François, MONTECUCCO, Fabrizio. Role of matrix metalloproteinase-8 in atherosclerosis. In: Mediators of Inflammation, 2013, vol. 2013, p. 659282. doi: 10.1155/2013/659282 https://archive-ouverte.unige.ch/unige:77509

286 hits



Deposited on : 2015-11-23

Export document
Format :
Citation style :