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Acute caffeine administration effect on brain activation patterns in mild cognitive impairment

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Published in Journal of Alzheimer's disease. 2014, vol. 41, no. 1, p. 101-112
Abstract Previous studies showed that acute caffeine administration enhances task-related brain activation in elderly individuals with preserved cognition. To explore the effects of this widely used agent on cognition and brain activation in early phases of cognitive decline, we performed a double-blinded, placebo-controlled functional magnetic resonance imaging (fMRI) study during an n-back working memory task in 17 individuals with mild cognitive impairment (MCI) compared to 17 age-matched healthy controls (HC). All individuals were regular caffeine consumers with an overnight abstinence and given 200 mg caffeine versus placebo tablets 30 minutes before testing. Analyses included assessment of task-related activation (general linear model), functional connectivity (tensorial-independent component analysis, TICA), baseline perfusion (arterial spin labeling, ASL), grey matter density (voxel-based morphometry, VBM), and white matter microstructure (tract-based spatial statistics, TBSS). Acute caffeine administration induced a focal activation of the prefrontal areas in HC with a more diffuse and posteromedial activation pattern in MCI individuals. In MCI, TICA documented a significant caffeine-related enhancement in the prefrontal cortex, supplementary motor area, ventral premotor and parietal cortex as well as the basal ganglia and cerebellum. The absence of significant group differences in baseline ASL perfusion patterns supports a neuronal rather than a purely vascular origin of these differences. The VBM and TBSS analyses excluded potentially confounding differences in grey matter density and white matter microstructure between MCI and HC. The present findings suggest a posterior displacement of working memory-related brain activation patterns after caffeine administration in MCI that may represent a compensatory mechanism to counterbalance a frontal lobe dysfunction.
Keywords AgedBrain/drug effects/pathology/physiopathologyBrain MappingCaffeine/pharmacologyCentral Nervous System Stimulants/pharmacologyCerebrovascular Circulation/drug effects/physiologyCross-Over StudiesDiffusion Tensor ImagingFemaleGray Matter/drug effects/pathology/physiopathologyHumansMagnetic Resonance ImagingMaleMemory, Short-Term/drug effects/physiologyMild Cognitive Impairment/drug therapy/pathology/physiopathologyNeural Pathways/drug effects/pathology/physiopathologyNeuropsychological TestsReaction Time/drug effectsSignal Processing, Computer-AssistedWhite Matter/drug effects/pathology/physiopathology
PMID: 24577471
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Research groups Groupe Giannakopoulos Panteleimon (psychiatrie générale) (201)
Ischémie cérébrale et connectivité (801)
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HALLER, Sven et al. Acute caffeine administration effect on brain activation patterns in mild cognitive impairment. In: Journal of Alzheimer's disease, 2014, vol. 41, n° 1, p. 101-112. doi: 10.3233/JAD-132360 https://archive-ouverte.unige.ch/unige:77125

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Deposited on : 2015-11-11

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